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- W1921896973 abstract "Viral infections in early childhood might play a role in causing lung damage in cystic fibrosis(CF). Aim: To study the respiratory viral burden during symptomatic and asymptomatic states of children with CF under 3 years in a community setting over one year. Methods: A longitudinal multi centric pilot study is being done in 3 tertiary care hospitals of Australia with CF Units.Parents of eligible children are enrolled and taught how to collect, mail the nasal swabs and record symptoms with validated methodology (Lambert, S.B. et al. Vaccine 2008; 26(15):1826-3).They were asked to collect one swab every fortnight and one during symptoms. Swabs were mailed to the laboratory in a viral transport tube. Samples were analyzed with PCR for a range of common respiratory viruses. Results: A total of 78 children were recruited. 946 nasal swabs were collected during 530 child months. Mean ARI rate was 0.4 episodes per child month. 913 swabs have been analyzed to date. 45.1% of parent reported symptom swabs and 19.5% of asymptomatic swabs were virus positive. The pattern of viruses isolated is as below. Conclusions: ARI rate, viral isolation in asymptomatic swabs, pattern of viruses is similar to previous studies. Isolation in symptom swabs(45.1%) is less than expected. Acute respiratory infections, viral isolation and virus carriage in children with CF is similar to that reported in children without lung conditions.Acknowledgements: Australian Cystic fibrosis Rsearch Trust & Telethon Foundation." @default.
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- W1921896973 date "2012-09-01" @default.
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- W1921896973 title "Respiratory infections in young children with cystic fibrosis: A community-based longitudinal study" @default.
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