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• W1921940299 abstract "<b>Objective</b> To investigate whether uterus preserving vaginal sacrospinous hysteropexy is non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments in the surgical treatment of uterine prolapse. <b>Design</b> Multicentre randomised controlled non-blinded non-inferiority trial. <b>Setting</b> 4 non-university teaching hospitals, the Netherlands. <b>Participants</b> 208 healthy women with uterine prolapse stage 2 or higher requiring surgery and no history of pelvic floor surgery. <b>Interventions</b> Treatment with sacrospinous hysteropexy or vaginal hysterectomy with suspension of the uterosacral ligaments. The predefined non-inferiority margin was an increase in surgical failure rate of 7%. <b>Main outcome measures</b> Primary outcome was recurrent prolapse stage 2 or higher of the uterus or vaginal vault (apical compartment) evaluated by the pelvic organ prolapse quantification system in combination with bothersome bulge symptoms or repeat surgery for recurrent apical prolapse at 12 months’ follow-up. Secondary outcomes were overall anatomical recurrences, including recurrent anterior compartment (bladder) and/or posterior compartment (bowel) prolapse, functional outcome, complications, hospital stay, postoperative recovery, and sexual functioning. <b>Results</b> Sacrospinous hysteropexy was non-inferior for anatomical recurrence of the apical compartment with bothersome bulge symptoms or repeat surgery (n=0, 0%) compared with vaginal hysterectomy with suspension of the uterosacral ligaments (n=4, 4.0%, difference −3.9%, 95% confidence interval for difference −8.6% to 0.7%). At 12 months, overall anatomical recurrences, functional outcome, quality of life, complications, hospital stay, measures on postoperative recovery, and sexual functioning did not differ between the two groups. Five serious adverse events were reported during hospital stay. None was considered to be related to the type of surgery. <b>Conclusions</b> Uterus preservation by sacrospinous hysteropexy was non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments for surgical failure of the apical compartment at 12 months’ follow-up. <b>Trial registration</b> trialregister.nl NTR1866." @default.
• W1921940299 created "2016-06-24" @default.
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• W1921940299 date "2015-07-23" @default.
• W1921940299 modified "2023-10-16" @default.
• W1921940299 title "Sacrospinous hysteropexy versus vaginal hysterectomy with suspension of the uterosacral ligaments in women with uterine prolapse stage 2 or higher: multicentre randomised non-inferiority trial" @default.
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• W1921940299 doi "https://doi.org/10.1136/bmj.h3717" @default.
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