Matches in SemOpenAlex for { <https://semopenalex.org/work/W1922016811> ?p ?o ?g. }
- W1922016811 endingPage "105" @default.
- W1922016811 startingPage "91" @default.
- W1922016811 abstract "In primary lymphoid organs, such as thymus and bone marrow, B and T lymphocytes differentiate from lymphoid stem cells into mature albeit naïve effector cells. In contrast, secondary lymphoid organs, such as the spleen, lymph nodes, and Peyer's patches (PPs), provide an environment that enable lymphocytes to interact with each other, with accessory cells, and with antigens, resulting in the initiation of antigen-specific primary immune responses. Recently, the analysis of gene-knockout mice has shed light on the signaling pathways, cellular requirements, and molecular mechanisms involved in secondary lymphoid organ development. In particular, signals that converge on the nuclear factor-kappaB (NF-kappaB) pathway have been demonstrated to play an important role in both early developmental steps as well as maintenance of secondary lymphoid organ structures. Analysis of the histopathological changes in secondary lymphoid tissues of mice lacking individual Rel/NF-kappaB family members, upstream kinases, and receptors strongly indicates that activation of the recently described alternative NF-kappaB pathway by membrane-bound lymphotoxin, via p52-RelB heterodimers, plays a major role during initiation steps of secondary lymphoid organ development. Induction of the classical p50-RelA NF-kappaB activity, as exemplified by tumor necrosis factor receptor signaling, clearly also contributes, but seems to be involved primarily in later developmental step, such as the proper cellular and structural organization of B-cell follicles." @default.
- W1922016811 created "2016-06-24" @default.
- W1922016811 creator A5049309702 @default.
- W1922016811 creator A5077808441 @default.
- W1922016811 date "2003-09-10" @default.
- W1922016811 modified "2023-09-27" @default.
- W1922016811 title "Regulation of secondary lymphoid organ development by the nuclear factor-��B signal transduction pathway" @default.
- W1922016811 cites W1495579988 @default.
- W1922016811 cites W1501881225 @default.
- W1922016811 cites W1508360975 @default.
- W1922016811 cites W1522382197 @default.
- W1922016811 cites W1534645474 @default.
- W1922016811 cites W1536379517 @default.
- W1922016811 cites W155134865 @default.
- W1922016811 cites W1558901013 @default.
- W1922016811 cites W1919878195 @default.
- W1922016811 cites W1935708014 @default.
- W1922016811 cites W1968013945 @default.
- W1922016811 cites W1970444129 @default.
- W1922016811 cites W1972379965 @default.
- W1922016811 cites W1973810160 @default.
- W1922016811 cites W1975773646 @default.
- W1922016811 cites W1976382352 @default.
- W1922016811 cites W1977348907 @default.
- W1922016811 cites W1977830503 @default.
- W1922016811 cites W1978019581 @default.
- W1922016811 cites W1981115336 @default.
- W1922016811 cites W1982062664 @default.
- W1922016811 cites W1982318766 @default.
- W1922016811 cites W1985831147 @default.
- W1922016811 cites W1987531976 @default.
- W1922016811 cites W1988502798 @default.
- W1922016811 cites W1991131833 @default.
- W1922016811 cites W1993620754 @default.
- W1922016811 cites W1997111007 @default.
- W1922016811 cites W2005970342 @default.
- W1922016811 cites W2006291443 @default.
- W1922016811 cites W2007456673 @default.
- W1922016811 cites W2007761469 @default.
- W1922016811 cites W2008596132 @default.
- W1922016811 cites W2008691047 @default.
- W1922016811 cites W2022153357 @default.
- W1922016811 cites W2025714343 @default.
- W1922016811 cites W2028910347 @default.
- W1922016811 cites W2032383673 @default.
- W1922016811 cites W2033018194 @default.
- W1922016811 cites W2033810895 @default.
- W1922016811 cites W2035616122 @default.
- W1922016811 cites W2035680000 @default.
- W1922016811 cites W2036368043 @default.
- W1922016811 cites W2039375273 @default.
- W1922016811 cites W2043150560 @default.
- W1922016811 cites W2045594979 @default.
- W1922016811 cites W2046975596 @default.
- W1922016811 cites W2049293744 @default.
- W1922016811 cites W2050633514 @default.
- W1922016811 cites W2051576341 @default.
- W1922016811 cites W2051818924 @default.
- W1922016811 cites W2053372168 @default.
- W1922016811 cites W2060019843 @default.
- W1922016811 cites W2061484658 @default.
- W1922016811 cites W2066574904 @default.
- W1922016811 cites W2069356140 @default.
- W1922016811 cites W2071082533 @default.
- W1922016811 cites W2071800797 @default.
- W1922016811 cites W2073292142 @default.
- W1922016811 cites W2078627220 @default.
- W1922016811 cites W2083734211 @default.
- W1922016811 cites W2087888785 @default.
- W1922016811 cites W2088094253 @default.
- W1922016811 cites W2092064162 @default.
- W1922016811 cites W2096589599 @default.
- W1922016811 cites W2101580628 @default.
- W1922016811 cites W2103944436 @default.
- W1922016811 cites W2111828502 @default.
- W1922016811 cites W2117327528 @default.
- W1922016811 cites W2117610610 @default.
- W1922016811 cites W2122559781 @default.
- W1922016811 cites W2133140093 @default.
- W1922016811 cites W2138004606 @default.
- W1922016811 cites W2142770698 @default.
- W1922016811 cites W2143937186 @default.
- W1922016811 cites W2145768405 @default.
- W1922016811 cites W2146520147 @default.
- W1922016811 cites W2147022432 @default.
- W1922016811 cites W2147507133 @default.
- W1922016811 cites W2147921405 @default.
- W1922016811 cites W2152561297 @default.
- W1922016811 cites W2153516407 @default.
- W1922016811 cites W2155471228 @default.
- W1922016811 cites W2159722075 @default.
- W1922016811 cites W2160546595 @default.
- W1922016811 cites W2160644552 @default.
- W1922016811 cites W2163139565 @default.
- W1922016811 cites W2163937409 @default.
- W1922016811 cites W2166475162 @default.
- W1922016811 cites W2168317635 @default.
- W1922016811 cites W2170430559 @default.