Matches in SemOpenAlex for { <https://semopenalex.org/work/W19222313> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W19222313 endingPage "835" @default.
- W19222313 startingPage "830" @default.
- W19222313 abstract "A 14‐day, randomized, open, phase I clinical trial was designed to examine possible pharmacokinetic interactions between rifabutin and two other antibiotics, azithro‐ mycin and clarithromycin, used in the treatment of Mycobacteritim avium complex infections. Thirty healthy male and female volunteers were divided into five groups of six participants each: 18 received 300 mg/day of rifabutin, 12 in combination with therapeutic doses of either azithromycin or clarithromycin; the remaining 12 received azithromycin or clarithromycin alone. On day 10 the study was terminated because of adverse events, including severe neutropenia. Fourteen participants who received rifabutin developed neutropenia, including all 12 participants who received azithromycin or clarithromycin concomitantly. Analyses of serum revealed no apparent pharmacokinetic interaction between azithromycin and rifabutin. However, the mean concentrations of rifabutin and 25‐O‐desacetyl‐rifabutin (an active metabolite) in participants who received clarithromycin and rifabutin concomitantly were more than 400% and 3,700%, respectively, of concentrations in those who received rifabutin alone. Physicians should be aware that recommended prophylactic doses of rifabutin may be associated with severe neutropenia within 2 weeks after initiation of therapy, and all patients receiving rifabutin, especially with clarithromycin, should be monitored carefully for neutropenia." @default.
- W19222313 created "2016-06-24" @default.
- W19222313 creator A5001983602 @default.
- W19222313 creator A5022252130 @default.
- W19222313 creator A5037325215 @default.
- W19222313 creator A5043542850 @default.
- W19222313 creator A5019908358 @default.
- W19222313 date "1998-09-01" @default.
- W19222313 modified "2023-10-03" @default.
- W19222313 title "Comparison of Azithromycin and Clarithromycin in Their Interactions with Rifabutin in Healthy Volunteers" @default.
- W19222313 cites W152635832 @default.
- W19222313 cites W180651789 @default.
- W19222313 cites W1974650490 @default.
- W19222313 cites W1985028001 @default.
- W19222313 cites W2006078265 @default.
- W19222313 cites W2007970667 @default.
- W19222313 cites W2008297056 @default.
- W19222313 cites W2024587809 @default.
- W19222313 cites W2043386100 @default.
- W19222313 cites W2044330754 @default.
- W19222313 cites W2059270564 @default.
- W19222313 cites W2059588998 @default.
- W19222313 cites W2073965718 @default.
- W19222313 cites W2081660660 @default.
- W19222313 cites W2102973576 @default.
- W19222313 cites W2124881865 @default.
- W19222313 cites W2413455418 @default.
- W19222313 cites W3129178518 @default.
- W19222313 cites W4256221661 @default.
- W19222313 doi "https://doi.org/10.1002/j.1552-4604.1998.tb00017.x" @default.
- W19222313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9753212" @default.
- W19222313 hasPublicationYear "1998" @default.
- W19222313 type Work @default.
- W19222313 sameAs 19222313 @default.
- W19222313 citedByCount "20" @default.
- W19222313 countsByYear W192223132015 @default.
- W19222313 countsByYear W192223132016 @default.
- W19222313 countsByYear W192223132017 @default.
- W19222313 countsByYear W192223132019 @default.
- W19222313 crossrefType "journal-article" @default.
- W19222313 hasAuthorship W19222313A5001983602 @default.
- W19222313 hasAuthorship W19222313A5019908358 @default.
- W19222313 hasAuthorship W19222313A5022252130 @default.
- W19222313 hasAuthorship W19222313A5037325215 @default.
- W19222313 hasAuthorship W19222313A5043542850 @default.
- W19222313 hasConcept C112705442 @default.
- W19222313 hasConcept C126322002 @default.
- W19222313 hasConcept C2776409635 @default.
- W19222313 hasConcept C2776694085 @default.
- W19222313 hasConcept C2776962512 @default.
- W19222313 hasConcept C2777063308 @default.
- W19222313 hasConcept C2778907293 @default.
- W19222313 hasConcept C2780867798 @default.
- W19222313 hasConcept C2781363766 @default.
- W19222313 hasConcept C3019249092 @default.
- W19222313 hasConcept C501593827 @default.
- W19222313 hasConcept C71924100 @default.
- W19222313 hasConcept C86803240 @default.
- W19222313 hasConcept C89423630 @default.
- W19222313 hasConcept C90924648 @default.
- W19222313 hasConcept C98274493 @default.
- W19222313 hasConceptScore W19222313C112705442 @default.
- W19222313 hasConceptScore W19222313C126322002 @default.
- W19222313 hasConceptScore W19222313C2776409635 @default.
- W19222313 hasConceptScore W19222313C2776694085 @default.
- W19222313 hasConceptScore W19222313C2776962512 @default.
- W19222313 hasConceptScore W19222313C2777063308 @default.
- W19222313 hasConceptScore W19222313C2778907293 @default.
- W19222313 hasConceptScore W19222313C2780867798 @default.
- W19222313 hasConceptScore W19222313C2781363766 @default.
- W19222313 hasConceptScore W19222313C3019249092 @default.
- W19222313 hasConceptScore W19222313C501593827 @default.
- W19222313 hasConceptScore W19222313C71924100 @default.
- W19222313 hasConceptScore W19222313C86803240 @default.
- W19222313 hasConceptScore W19222313C89423630 @default.
- W19222313 hasConceptScore W19222313C90924648 @default.
- W19222313 hasConceptScore W19222313C98274493 @default.
- W19222313 hasIssue "9" @default.
- W19222313 hasLocation W192223131 @default.
- W19222313 hasLocation W192223132 @default.
- W19222313 hasOpenAccess W19222313 @default.
- W19222313 hasPrimaryLocation W192223131 @default.
- W19222313 hasRelatedWork W19222313 @default.
- W19222313 hasRelatedWork W1973454072 @default.
- W19222313 hasRelatedWork W2024823712 @default.
- W19222313 hasRelatedWork W2045125253 @default.
- W19222313 hasRelatedWork W2053980222 @default.
- W19222313 hasRelatedWork W2057103226 @default.
- W19222313 hasRelatedWork W2100406698 @default.
- W19222313 hasRelatedWork W2133152745 @default.
- W19222313 hasRelatedWork W2171976973 @default.
- W19222313 hasRelatedWork W2414496544 @default.
- W19222313 hasVolume "38" @default.
- W19222313 isParatext "false" @default.
- W19222313 isRetracted "false" @default.
- W19222313 magId "19222313" @default.
- W19222313 workType "article" @default.