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• W1922466054 abstract "Mitochondria are essential for oxidative energy production in aerobic eukaryotic cells, where they are also required for multiple biosynthetic pathways to take place. Mitochondria also monitor and evaluate complex information from the environment and intracellular milieu, including the presence or absence of growth factors, oxygen, reactive oxygen species, and DNA damage. It follows that disturbances of the integrity of mitochondrial function lead to the disruption of cell function, expressed as disease, aging, or cell death. It has been assumed that the degradation of damaged mitochondria by an autophagy-related pathway specific to mitochondria (mitophagy), recently found to be strictly regulated, is a fundamental process essential for cell homeostasis. Until now, the main role of mitophagy has been tentatively defined as a 'house-cleaning' pathway that allows to eliminate altered mitochondria, but mitophagy may also play a role in the adaptation of the number and quality of mitochondria to new environmental conditions. In yeast, recent data defined two categories of mitophagy actors: ones constitutively required for mitophagy and those with mitophagy-regulatory functions. Situations were also uncovered in normal physiology in which cells utilize mitophagy to eliminate damaged, dysfunctional, and superfluous mitochondria to adjust to changing physiological demands." @default.
• W1922466054 created "2016-06-24" @default.
• W1922466054 creator A5023137320 @default.
• W1922466054 creator A5088946022 @default.
• W1922466054 date "2010-11-05" @default.
• W1922466054 modified "2023-09-25" @default.
• W1922466054 title "Mitophagy in yeast: actors and physiological roles" @default.
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• W1922466054 doi "https://doi.org/10.1111/j.1567-1364.2010.00659.x" @default.
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