FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1922485026> ?p ?o ?g. }

• W1922485026 abstract "Determining the prerequisites for healthy aging is a major task in the modern world characterized by a longer lifespan of the individuals. Besides lifestyle and environmental influences genetic factors are involved as shown by several genome-wide association studies. Older individuals are known to have an impaired immune response, a condition recently termed inflamm-aging. We hypothesize that the induction of this condition in the elderly is influenced by the sensitivity of the innate immune system. Therefore, we investigated genetic variants of the Toll-like receptor (TLR) family, one of the major family of innate immune receptors, for association with age in two cohorts of healthy, disease-free subjects.According to sex we found a positive association of loss-of-function variants of TLR-1 and -6 with healthy aging with odds ratios of 1.54 in males for TLR-6 (249 S/S), and 1.41, 1.66, and 1.64 in females for TLR-1 prom., TLR-1 (248 S/S), and TLR-1 (602 S/S), respectively. Thus, the presence of these variants increases the probability of achieving healthy old age and indicates that a reduced TLR activity may be beneficial in the elderly.This is the first report showing an association of TLR variants with age. While a loss of function of an important immune receptor may be a risk factor for acute infections as has been shown previously, in the setting of healthy ageing it appears to be protective, which may relate to inflamm-aging. These first results should be reproduced in larger trials to confirm this hypothesis." @default.
• W1922485026 created "2016-06-24" @default.
• W1922485026 creator A5020269983 @default.
• W1922485026 creator A5037828878 @default.
• W1922485026 creator A5047850369 @default.
• W1922485026 creator A5053887656 @default.
• W1922485026 creator A5055231578 @default.
• W1922485026 creator A5066086405 @default.
• W1922485026 creator A5073345578 @default.
• W1922485026 date "2015-07-08" @default.
• W1922485026 modified "2023-10-11" @default.
• W1922485026 title "Less functional variants of TLR-1/-6/-10 genes are associated with age" @default.
• W1922485026 cites W1549704455 @default.
• W1922485026 cites W1953329867 @default.
• W1922485026 cites W1964545325 @default.
• W1922485026 cites W1968377406 @default.
• W1922485026 cites W1977408830 @default.
• W1922485026 cites W1993197717 @default.
• W1922485026 cites W1997412308 @default.
• W1922485026 cites W1997758798 @default.
• W1922485026 cites W1999298001 @default.
• W1922485026 cites W1999381834 @default.
• W1922485026 cites W2012394149 @default.
• W1922485026 cites W2013912351 @default.
• W1922485026 cites W2030579395 @default.
• W1922485026 cites W2032146891 @default.
• W1922485026 cites W2038820219 @default.
• W1922485026 cites W2043317121 @default.
• W1922485026 cites W2053574951 @default.
• W1922485026 cites W2059218077 @default.
• W1922485026 cites W2066299623 @default.
• W1922485026 cites W2072130124 @default.
• W1922485026 cites W2074949522 @default.
• W1922485026 cites W2078120857 @default.
• W1922485026 cites W2078558690 @default.
• W1922485026 cites W2084026374 @default.
• W1922485026 cites W2089500922 @default.
• W1922485026 cites W2092591554 @default.
• W1922485026 cites W2093797646 @default.
• W1922485026 cites W2105617732 @default.
• W1922485026 cites W2107762058 @default.
• W1922485026 cites W2115145729 @default.
• W1922485026 cites W2118214974 @default.
• W1922485026 cites W2122483069 @default.
• W1922485026 cites W2124266557 @default.
• W1922485026 cites W2128738903 @default.
• W1922485026 cites W2132507498 @default.
• W1922485026 cites W2132552679 @default.
• W1922485026 cites W2138755473 @default.
• W1922485026 cites W2140006882 @default.
• W1922485026 cites W2142563401 @default.
• W1922485026 cites W2145762862 @default.
• W1922485026 cites W2146977889 @default.
• W1922485026 cites W2152536923 @default.
• W1922485026 cites W2160874046 @default.
• W1922485026 cites W2161289428 @default.
• W1922485026 cites W4247538071 @default.
• W1922485026 doi "https://doi.org/10.1186/s12979-015-0034-z" @default.
• W1922485026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4495943" @default.
• W1922485026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26157469" @default.
• W1922485026 hasPublicationYear "2015" @default.
• W1922485026 type Work @default.
• W1922485026 sameAs 1922485026 @default.
• W1922485026 citedByCount "6" @default.
• W1922485026 countsByYear W19224850262015 @default.
• W1922485026 countsByYear W19224850262016 @default.
• W1922485026 countsByYear W19224850262019 @default.
• W1922485026 countsByYear W19224850262021 @default.
• W1922485026 crossrefType "journal-article" @default.
• W1922485026 hasAuthorship W1922485026A5020269983 @default.
• W1922485026 hasAuthorship W1922485026A5037828878 @default.
• W1922485026 hasAuthorship W1922485026A5047850369 @default.
• W1922485026 hasAuthorship W1922485026A5053887656 @default.
• W1922485026 hasAuthorship W1922485026A5055231578 @default.
• W1922485026 hasAuthorship W1922485026A5066086405 @default.
• W1922485026 hasAuthorship W1922485026A5073345578 @default.
• W1922485026 hasBestOaLocation W19224850261 @default.
• W1922485026 hasConcept C126322002 @default.
• W1922485026 hasConcept C136449434 @default.
• W1922485026 hasConcept C156957248 @default.
• W1922485026 hasConcept C203014093 @default.
• W1922485026 hasConcept C2776709828 @default.
• W1922485026 hasConcept C2779056147 @default.
• W1922485026 hasConcept C2779134260 @default.
• W1922485026 hasConcept C500499127 @default.
• W1922485026 hasConcept C54355233 @default.
• W1922485026 hasConcept C71924100 @default.
• W1922485026 hasConcept C86803240 @default.
• W1922485026 hasConcept C8891405 @default.
• W1922485026 hasConceptScore W1922485026C126322002 @default.
• W1922485026 hasConceptScore W1922485026C136449434 @default.
• W1922485026 hasConceptScore W1922485026C156957248 @default.
• W1922485026 hasConceptScore W1922485026C203014093 @default.
• W1922485026 hasConceptScore W1922485026C2776709828 @default.
• W1922485026 hasConceptScore W1922485026C2779056147 @default.
• W1922485026 hasConceptScore W1922485026C2779134260 @default.
• W1922485026 hasConceptScore W1922485026C500499127 @default.
• W1922485026 hasConceptScore W1922485026C54355233 @default.
• W1922485026 hasConceptScore W1922485026C71924100 @default.
• W1922485026 hasConceptScore W1922485026C86803240 @default.

• next