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- W192248829 abstract "Publisher Summary The pituitary gland is a versatile hormonal interface between the nervous system and the rest of the body, a warehouse of peptides waiting for nervous requisitions. In mammals, the anterior pituitary can secrete at least six major peptide hormones from at least five cell types. Each cell is under the control of specific releasing hormones and neurotransmitters secreted into the pituitary portal circulation by hypothalamic neurons. This chapter describes a study of G protein-mediated modulation of ion channels, which involved working with muscarinic activation of a K+ channel in cardiac trial cells and GnRH and muscarinic inhibition of a K+ channel in frog sympathetic ganglia, where GnRH was a neurotransmitter. The work with GnRH has explained the activities of gondaotrope, where a chain of events is triggered by GnRH. The primary secretory response to GnRH is unambiguously attributable to a steady rise of IP3that leads to an oscillatory release of Ca2+ from intracellular stores. Each elevation brings [Ca2+]i well above the 300 nM level that suffices to initiate exocytosis of numerous secretory granules. The secretory stimulus for gonadotropes does not initiate a major entry of extracellular Ca2+ as a primary signal for exocytosis. The electrophysiological responses of stimulated gonadotropes include a hyperpolarization during periods of [Ca2+]i rise instead of a depolarization." @default.
- W192248829 created "2016-06-24" @default.
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- W192248829 creator A5049507794 @default.
- W192248829 creator A5074482605 @default.
- W192248829 date "1995-01-01" @default.
- W192248829 modified "2023-09-23" @default.
- W192248829 title "Signaling Mechanisms during the Response of Pituitary Gonadotropes to GnRH" @default.
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- W192248829 doi "https://doi.org/10.1016/b978-0-12-571150-0.50008-1" @default.
- W192248829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7740186" @default.
- W192248829 hasPublicationYear "1995" @default.
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