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- W192256712 abstract "Publisher Summary This chapter focuses on the direct introduction of macromolecules into the cytoplasm through cell fusion mediated by Sendai virus, hemagglutinating virus (HVJ) of Japan. HVJ-liposomes are applicable for gene transfer to all cells but lymphocytes. Development in the use of this method has resulted in delivery of antisense oligonucleotides into the nuclei of cells in vitro and in vivo, where the antisense oligonucleotides are remarkably stable more than 2 weeks, with long-term suppression of expression of the corresponding gene. In terms of the biological safety of HVJ, although mice suffer from severe pneumonia, the UV-inactivated virus is harmless. The virus is treated with detergent, heat, and UV irradiation." @default.
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- W192256712 date "1994-01-01" @default.
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- W192256712 title "Virus (Sendai Virus Envelopes)-Mediated Gene Transfer" @default.
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- W192256712 doi "https://doi.org/10.1016/b978-0-12-164717-9.50011-8" @default.
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