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• W1922668004 abstract "Reactive oxygen species regulate cardiovascular and renal function in health and disease. Superoxide participates in acute calcium signaling in afferent arterioles and renal vasoconstriction produced by angiotensin II, endothelin, thromboxane, and pressure-induced myogenic tone. Known mechanisms by which superoxide acts include quenching of nitric oxide and increased ADP ribosyl cyclase/ryanodine-mediated calcium mobilization. The effect(s) of superoxide on other calcium signaling pathways in the renal microcirculation is poorly understood. The present experiments examined the acute effect of superoxide generated by paraquat on calcium entry pathways in isolated rat afferent arterioles. The peak increase in cytosolic calcium concentration caused by KCl (40 mmol/L) was 99±14 nmol/L. The response to this membrane depolarization was mediated exclusively by L-type channels because it was abolished by nifedipine but was unaffected by the T-type channel blocker mibefradil. Paraquat increased superoxide production (dihydroethidium fluorescence), tripled the peak response to KCl to 314±68 nmol/L (P<0.001) and doubled the plateau response. These effects were abolished by tempol and nitroblue tetrazolium, but not by catalase, confirming actions of superoxide and not of hydrogen peroxide. Unaffected by paraquat and superoxide was calcium entry through store-operated calcium channels activated by thapsigargin-induced calcium depletion of sarcoplasmic reticular stores. Also unresponsive to paraquat was ryanodine receptor-mediated calcium-induced calcium release from the sarcoplasmic reticulum. Our results provide new evidence that superoxide enhances calcium entry through L-type channels activated by membrane depolarization in rat cortical afferent arterioles, without affecting calcium entry through store-operated entry or ryanodine receptor-mediated calcium mobilization." @default.
• W1922668004 created "2016-06-24" @default.
• W1922668004 creator A5040874689 @default.
• W1922668004 creator A5060167913 @default.
• W1922668004 creator A5060883709 @default.
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• W1922668004 date "2015-08-01" @default.
• W1922668004 modified "2023-10-18" @default.
• W1922668004 title "Superoxide Enhances Ca ²⁺ Entry Through L-Type Channels in the Renal Afferent Arteriole" @default.
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• W1922668004 doi "https://doi.org/10.1161/hypertensionaha.115.05274" @default.
• W1922668004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4499026" @default.
• W1922668004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26034201" @default.
• W1922668004 hasPublicationYear "2015" @default.
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