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- W1922786159 endingPage "181" @default.
- W1922786159 startingPage "165" @default.
- W1922786159 abstract "Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. The domains of the S1S2 ligand binding core are expanded in the apo state and contract upon ligand binding with the extent of domain separation decreasing in the order of apo > DNQX > kainate > glutamate ≅ AMPA. These results suggest that agonist-induced domain closure gates the transmembrane channel and the extent of receptor activation depends upon the degree of domain closure. AMPA and glutamate also promote a 180° flip of a trans peptide bond in the ligand binding site. The crystal packing of the ligand binding cores suggests modes for subunit–subunit contact in the intact receptor and mechanisms by which allosteric effectors modulate receptor activity." @default.
- W1922786159 created "2016-06-24" @default.
- W1922786159 creator A5017096524 @default.
- W1922786159 creator A5088125571 @default.
- W1922786159 date "2000-10-01" @default.
- W1922786159 modified "2023-10-18" @default.
- W1922786159 title "Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor" @default.
- W1922786159 cites W1492554871 @default.
- W1922786159 cites W1506811553 @default.
- W1922786159 cites W1521025514 @default.
- W1922786159 cites W1523646668 @default.
- W1922786159 cites W1537256933 @default.
- W1922786159 cites W1539796472 @default.
- W1922786159 cites W1551088980 @default.
- W1922786159 cites W1567416559 @default.
- W1922786159 cites W1587655960 @default.
- W1922786159 cites W1594006457 @default.
- W1922786159 cites W1594147709 @default.
- W1922786159 cites W1594989334 @default.
- W1922786159 cites W1633846818 @default.
- W1922786159 cites W1744070583 @default.
- W1922786159 cites W1849447163 @default.
- W1922786159 cites W1908222510 @default.
- W1922786159 cites W1964310407 @default.
- W1922786159 cites W1965277349 @default.
- W1922786159 cites W1965504075 @default.
- W1922786159 cites W1966681799 @default.
- W1922786159 cites W1968311472 @default.
- W1922786159 cites W1969156185 @default.
- W1922786159 cites W1970388012 @default.
- W1922786159 cites W1975275982 @default.
- W1922786159 cites W1978817835 @default.
- W1922786159 cites W1984882112 @default.
- W1922786159 cites W1986923087 @default.
- W1922786159 cites W1989363688 @default.
- W1922786159 cites W1991647860 @default.
- W1922786159 cites W1993560924 @default.
- W1922786159 cites W1994343723 @default.
- W1922786159 cites W1998775373 @default.
- W1922786159 cites W2003111769 @default.
- W1922786159 cites W2005913521 @default.
- W1922786159 cites W2006406301 @default.
- W1922786159 cites W2006606811 @default.
- W1922786159 cites W2007051067 @default.
- W1922786159 cites W2009297045 @default.
- W1922786159 cites W2013973914 @default.
- W1922786159 cites W2019019017 @default.
- W1922786159 cites W2020370168 @default.
- W1922786159 cites W2020818940 @default.
- W1922786159 cites W2027343672 @default.
- W1922786159 cites W2032124745 @default.
- W1922786159 cites W2037772094 @default.
- W1922786159 cites W2040026786 @default.
- W1922786159 cites W2040720735 @default.
- W1922786159 cites W2042732542 @default.
- W1922786159 cites W2043873927 @default.
- W1922786159 cites W2045637142 @default.
- W1922786159 cites W2054750550 @default.
- W1922786159 cites W2057537207 @default.
- W1922786159 cites W2063461600 @default.
- W1922786159 cites W2063987809 @default.
- W1922786159 cites W2064104812 @default.
- W1922786159 cites W2072476822 @default.
- W1922786159 cites W2075711246 @default.
- W1922786159 cites W2075770210 @default.
- W1922786159 cites W2077211332 @default.
- W1922786159 cites W2080476827 @default.
- W1922786159 cites W2081734691 @default.
- W1922786159 cites W2081912151 @default.
- W1922786159 cites W2084877235 @default.
- W1922786159 cites W2086050619 @default.
- W1922786159 cites W2088809305 @default.
- W1922786159 cites W2089116626 @default.
- W1922786159 cites W2091763641 @default.
- W1922786159 cites W2091765514 @default.
- W1922786159 cites W2110847661 @default.
- W1922786159 cites W2117177933 @default.
- W1922786159 cites W2124706705 @default.
- W1922786159 cites W2129108032 @default.
- W1922786159 cites W2130227962 @default.
- W1922786159 cites W2134083569 @default.
- W1922786159 cites W2143070723 @default.
- W1922786159 cites W2153240389 @default.
- W1922786159 cites W2154239194 @default.
- W1922786159 cites W2155921225 @default.
- W1922786159 cites W2157390039 @default.
- W1922786159 cites W2162520530 @default.
- W1922786159 cites W2167689408 @default.
- W1922786159 cites W2171021618 @default.
- W1922786159 cites W2411701695 @default.
- W1922786159 cites W2949797653 @default.
- W1922786159 cites W4211044690 @default.
- W1922786159 doi "https://doi.org/10.1016/s0896-6273(00)00094-5" @default.
- W1922786159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11086992" @default.
- W1922786159 hasPublicationYear "2000" @default.
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