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- W1923197190 abstract "Abstract Introduction Since F ebruary 2013, a novel reassortant H7N 9 virus associated with human deaths, but no apparent outbreaks in poultry and wild birds has emerged in eastern C hina. Objectives The potential reemergence of H7N 9 during next year's influenza season demand a further understanding of this important disease. Methods Between M arch 1 and A pril 30, 2013, we obtained and analyzed clinical, epidemiologic and radiologic features, and virologic data from three laboratory‐confirmed patients of A H7N 9 infection admitted in S hanghai R uijin H ospital. Results All patients were middle to old aged (mean age 62 years) and overweight (mean body mass index 31) patients. Two patients were exposed to poultry directly or indirectly in food market. They presented with fever and rapidly progressive pneumonia that did not respond to antibiotics. Time between onset of symptoms and onset of respiratory failure (days) were 7–11 days. Two patients presented secondary invasive bacterial infections. All patients died on day 7 to day 86 after the onset of symptoms. Conclusions Cross species poultry‐to‐person transmission of this new reassortant avian influenza H7N 9 virus can result in severe and fatal respiratory disease like acute respiratory distress syndrome ( ARDS ) in humans. Reduplicate chest imaging examination is suggested for risky patients with fever and dyspnea. Secondary invasive bacterial infections and pneumothorax can cause severe and fatal consequence. Old age, obesity and presence of comorbidity may be associated with increased mortality. Pulmonary fibrosis can be seen at late stage of the disease." @default.
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- W1923197190 date "2014-01-10" @default.
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- W1923197190 title "Clinical features of three avian influenza H7N9 virus-infected patients in Shanghai" @default.
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- W1923197190 doi "https://doi.org/10.1111/crj.12087" @default.
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