FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1923491844> ?p ?o ?g. }

• W1923491844 endingPage "898" @default.
• W1923491844 startingPage "889" @default.
• W1923491844 abstract "Background: Conjugated linoleic acid (CLA), a naturally occurring linoleic acid isomer found in ruminant-produced foods, has the potential to serve as an effective chemopreventive nutriceutical factor for breast cancer prevention based upon previous published studies. There are several CLA isomers in ruminant-produced food products, among which t10, c12-CLA and c9, t11-CLA are more potent. Expression of cyclooxygenase 2 (COX-2) in mammary tumors has been correlated with poor prognosis. Prostaglandin E2 (PGE2) is a major COX-2 product in various cancers and, as in humans, PGE2 concentrations in canine tumor tissues were frequently elevated. Moreover, a PGE2 receptor subtype, EP2, is highly expressed in mammary tumors. Thus, various studies have implicated the important role of PGE2 and EP2 in COX-2-regulated tumor development. Materials and Methods: Mammary tumor and normal mammary tissues were both collected from a female dog with mammary tumor. Both malignant and normal mammary tissues were subjected to isolation of epithelial and stromal cells. The effects of t10, c12-CLA and c9, t11-CLA on proliferation, as well as COX-2 and EP2 protein expression in canine mammary normal and cancerous cells, were detected by CellTiter 96i AQueous assay and Western blot assay, respectively. Results: Both t10, c12-CLA and c9, t11-CLA not only suppressed malignant mammary cell growth, but also exerted inhibitory effects on tumor-associated non-malignant mammary cells. Similarly, both t10, c12-CLA and c9, t11-CLA suppressed EP2 protein expression in both normal and malignant mammary cells. t10, c12-CLA was more effective in decreasing COX-2 protein expression in malignant mammary cells, while, in contrast, c9, t11-CLA down-regulated COX-2 protein expression in both normal and malignant mammary cells. Conclusion: The results indicate that the dietary component CLA regulates COX-2 and EP2 protein expression in both malignant mammary cells and cells from the tumor-associated stromal compartment. In turn, this may suppress PGE2 signaling, leading to better prognosis. We further speculate that the knowledge obtained from canine studies may also be beneficial to study human breast cancer." @default.
• W1923491844 created "2016-06-24" @default.
• W1923491844 creator A5009099603 @default.
• W1923491844 creator A5016525715 @default.
• W1923491844 creator A5017320914 @default.
• W1923491844 creator A5033546545 @default.
• W1923491844 creator A5034627295 @default.
• W1923491844 creator A5044263097 @default.
• W1923491844 creator A5064379764 @default.
• W1923491844 creator A5066786439 @default.
• W1923491844 creator A5067962918 @default.
• W1923491844 creator A5082254990 @default.
• W1923491844 creator A5091837032 @default.
• W1923491844 date "2006-03-01" @default.
• W1923491844 modified "2023-10-03" @default.
• W1923491844 title "Conjugated Linoleic Acid (CLA) Modulates Prostaglandin E2 (PGE2) Signaling in Canine Mammary Cells" @default.
• W1923491844 cites W1480357432 @default.
• W1923491844 cites W1557488623 @default.
• W1923491844 cites W1570733029 @default.
• W1923491844 cites W1645877188 @default.
• W1923491844 cites W1965992514 @default.
• W1923491844 cites W1970085289 @default.
• W1923491844 cites W1975826537 @default.
• W1923491844 cites W1984921618 @default.
• W1923491844 cites W1992963174 @default.
• W1923491844 cites W1995528018 @default.
• W1923491844 cites W1996059533 @default.
• W1923491844 cites W2001733842 @default.
• W1923491844 cites W2001779498 @default.
• W1923491844 cites W2012801178 @default.
• W1923491844 cites W2013745776 @default.
• W1923491844 cites W2020803551 @default.
• W1923491844 cites W2022805432 @default.
• W1923491844 cites W2037099316 @default.
• W1923491844 cites W2042353657 @default.
• W1923491844 cites W2045885767 @default.
• W1923491844 cites W2046452406 @default.
• W1923491844 cites W2046693139 @default.
• W1923491844 cites W2049433363 @default.
• W1923491844 cites W205782301 @default.
• W1923491844 cites W2058026824 @default.
• W1923491844 cites W2059344419 @default.
• W1923491844 cites W2063841251 @default.
• W1923491844 cites W2067608498 @default.
• W1923491844 cites W2072415845 @default.
• W1923491844 cites W2072838912 @default.
• W1923491844 cites W2091562897 @default.
• W1923491844 cites W2094519127 @default.
• W1923491844 cites W2106291858 @default.
• W1923491844 cites W2110809844 @default.
• W1923491844 cites W2123427472 @default.
• W1923491844 cites W2128966132 @default.
• W1923491844 cites W2129202730 @default.
• W1923491844 cites W2136574231 @default.
• W1923491844 cites W2139199726 @default.
• W1923491844 cites W2139776244 @default.
• W1923491844 cites W2140877509 @default.
• W1923491844 cites W2141751852 @default.
• W1923491844 cites W2144164082 @default.
• W1923491844 cites W2145105354 @default.
• W1923491844 cites W2148757768 @default.
• W1923491844 cites W2150604017 @default.
• W1923491844 cites W2160616140 @default.
• W1923491844 cites W2161457867 @default.
• W1923491844 cites W2162592603 @default.
• W1923491844 cites W2163935379 @default.
• W1923491844 cites W2165817371 @default.
• W1923491844 cites W2168051211 @default.
• W1923491844 cites W2330496155 @default.
• W1923491844 cites W2417754689 @default.
• W1923491844 cites W2981965471 @default.
• W1923491844 cites W1795717998 @default.
• W1923491844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16619484" @default.
• W1923491844 hasPublicationYear "2006" @default.
• W1923491844 type Work @default.
• W1923491844 sameAs 1923491844 @default.
• W1923491844 citedByCount "10" @default.
• W1923491844 countsByYear W19234918442013 @default.
• W1923491844 countsByYear W19234918442018 @default.
• W1923491844 countsByYear W19234918442022 @default.
• W1923491844 countsByYear W19234918442023 @default.
• W1923491844 crossrefType "journal-article" @default.
• W1923491844 hasAuthorship W1923491844A5009099603 @default.
• W1923491844 hasAuthorship W1923491844A5016525715 @default.
• W1923491844 hasAuthorship W1923491844A5017320914 @default.
• W1923491844 hasAuthorship W1923491844A5033546545 @default.
• W1923491844 hasAuthorship W1923491844A5034627295 @default.
• W1923491844 hasAuthorship W1923491844A5044263097 @default.
• W1923491844 hasAuthorship W1923491844A5064379764 @default.
• W1923491844 hasAuthorship W1923491844A5066786439 @default.
• W1923491844 hasAuthorship W1923491844A5067962918 @default.
• W1923491844 hasAuthorship W1923491844A5082254990 @default.
• W1923491844 hasAuthorship W1923491844A5091837032 @default.
• W1923491844 hasConcept C121608353 @default.
• W1923491844 hasConcept C126322002 @default.
• W1923491844 hasConcept C134018914 @default.
• W1923491844 hasConcept C170493617 @default.
• W1923491844 hasConcept C178592051 @default.

• next