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• W1923514476 endingPage "3148" @default.
• W1923514476 startingPage "3134" @default.
• W1923514476 abstract "Mammalian hybrids often show abnormal growth, indicating that developmental inviability may play an important role in mammalian speciation. Yet, it is unclear if this recurrent phenotype reflects a common genetic basis. Here, we describe extreme parent-of-origin-dependent growth in hybrids from crosses between two species of dwarf hamsters, Phodopus campbelli and Phodopus sungorus. One cross type resulted in massive placental and embryonic overgrowth, severe developmental defects, and maternal death. Embryos from the reciprocal cross were viable and normal sized, but adult hybrid males were relatively small. These effects are strikingly similar to patterns from several other mammalian hybrids. Using comparative sequence data from dwarf hamsters and several other hybridizing mammals, we argue that extreme hybrid growth can contribute to reproductive isolation during the early stages of species divergence. Next, we tested if abnormal growth in hybrid hamsters was associated with disrupted genomic imprinting. We found no association between imprinting status at several candidate genes and hybrid growth, though two interacting genes involved in embryonic growth did show reduced expression in overgrown hybrids. Collectively, our study indicates that growth-related hybrid inviability may play an important role in mammalian speciation but that the genetic underpinnings of these phenotypes remain unresolved." @default.
• W1923514476 created "2016-06-24" @default.
• W1923514476 creator A5007258205 @default.
• W1923514476 creator A5046681707 @default.
• W1923514476 date "2014-09-10" @default.
• W1923514476 modified "2023-10-10" @default.
• W1923514476 title "Parent‐of‐origin growth effects and the evolution of hybrid inviability in dwarf hamsters" @default.
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