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• W1923725448 abstract "Background People with cystic fibrosis (CF) sinus disease have developmental sinus abnormalities with airway bacterial infection, inflammation, impaired mucociliary clearance and thick obstructive mucus. The pathophysiology of airway disease in CF is not completely understood, and current treatments in CF sinus disease ameliorate symptoms but do not provide a cure. Methods This manuscript reviews the history of CF, its manifestations in sinus disease, and the potential impact and relationship of CF on the upper and lower airway. Results There is increasing evidence that CF sinus disease may affect CF lung disease, the most common cause of mortality in CF. We have been limited in treating the symptoms of advanced CF sinus disease with our current therapies. Conclusions Recent discoveries in the pathophysiology of CF using the CF porcine animal model and exciting treatments that address the primary gene defect that may translate into improved outcomes in CF and non‐CF sinusitis in humans." @default.
• W1923725448 created "2016-06-24" @default.
• W1923725448 creator A5047622778 @default.
• W1923725448 date "2013-11-26" @default.
• W1923725448 modified "2023-10-16" @default.
• W1923725448 title "New insights into the pathogenesis of cystic fibrosis sinusitis" @default.
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• W1923725448 doi "https://doi.org/10.1002/alr.21252" @default.
• W1923725448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3946531" @default.
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