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- W192374311 abstract "In 1940 Kellaway and Trethewie reported that perfusate from antigen- stimulated, resected lung of sensitized guinea pigs produced a slowly developing contraction of isolated guinea pig ileum. The name slow-reacting substance of anaphylaxis (SRS-A) was coined to describe the unknown substance(s) mediating this contractile activity. Over the next 30 years a few investigators studied the release of SRS-A from different sources and attempted to purify the highly labile material. Early in the 1970s, scientists from Fisons Ltd. (Augstein et al., 1973) described the discovery of FPL 55712 (Structure 6-A), a relatively potent and competitive antagonist of SRS-A. The compound was identified serendipitously as part of a screening effort at Fisons to identify more potent analogs of their antiasthma drug disodium cromoglycate. While FPL 55712 proved to be relatively nonselective1 and too metabolically labile to serve as a drug, it became an important pharmacological tool for the evaluation of SRS-A and spurred a resurgence of interest in that substance." @default.
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- W192374311 date "1995-01-01" @default.
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- W192374311 title "Discovery of Accolate™ (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma" @default.
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