FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1923790426> ?p ?o ?g. }

• W1923790426 endingPage "1653" @default.
• W1923790426 startingPage "1643" @default.
• W1923790426 abstract "Motoneurons seem to require contact with their target muscle even after embryogenesis is complete, but the consequences of target-deprivation during postnatal development are poorly understood. To examine the fate of motoneurons separated from their targets postnatally, we labeled the motoneurons that innervate the biceps brachii muscle with the retrograde tracer Fluorogold and then separated them from their muscle by amputating the forelimb. Fluorogold was subsequently found within motoneurons, as well as within much smaller cells that were identified as microglia. The number of labeled microglial cells steadily increased with time following limb amputation, while the number of labeled motoneurons declined. The magnitude of this response depended on the age of the animal: the younger the animal at the time of the amputation, the greater the number of labeled microglia and the more extensive the neuronal loss. To ensure that the response to amputation was caused by target deprivation, rather than by the injury itself, the nerve to the biceps muscle was cut or crushed. In this way, axons were transected but target access was only temporarily denied. After the nerve was cut, motoneurons began to reinnervate the muscle within 3 weeks but, just as after amputation, the spinal cord subsequently contained labeled microglia and a reduced number of motoneurons. In contrast, after nerve crush, reinnervation began within 4 d and there was no evidence of motoneuron death. Our results demonstrate that target-deprivation causes motoneurons to be lost in an age- and time-dependent manner, and indicate a critical period after axotomy during which motoneurons must reinnervate their target in order to survive. Further, we provide evidence that microglial cells may phagocytose dying motoneurons. The approach we used would provide a convenient assay for testing candidate motoneuron growth factors in animals where in vivo studies of the embryo are difficult." @default.
• W1923790426 created "2016-06-24" @default.
• W1923790426 creator A5060332325 @default.
• W1923790426 creator A5080599051 @default.
• W1923790426 date "1990-05-01" @default.
• W1923790426 modified "2023-09-27" @default.
• W1923790426 title "The dependence of motoneurons on their target muscle during postnatal development of the mouse" @default.
• W1923790426 cites W1030693451 @default.
• W1923790426 cites W142080826 @default.
• W1923790426 cites W1581184243 @default.
• W1923790426 cites W1609471181 @default.
• W1923790426 cites W1646206347 @default.
• W1923790426 cites W1784248652 @default.
• W1923790426 cites W1880073789 @default.
• W1923790426 cites W1968860081 @default.
• W1923790426 cites W1969943683 @default.
• W1923790426 cites W1979566783 @default.
• W1923790426 cites W1989254326 @default.
• W1923790426 cites W1990189304 @default.
• W1923790426 cites W1993995496 @default.
• W1923790426 cites W1997373028 @default.
• W1923790426 cites W1997831655 @default.
• W1923790426 cites W2006572247 @default.
• W1923790426 cites W2022021003 @default.
• W1923790426 cites W2040095427 @default.
• W1923790426 cites W2042507949 @default.
• W1923790426 cites W2045184108 @default.
• W1923790426 cites W2048312967 @default.
• W1923790426 cites W2052659902 @default.
• W1923790426 cites W2054771445 @default.
• W1923790426 cites W2054876379 @default.
• W1923790426 cites W2055411409 @default.
• W1923790426 cites W2059819806 @default.
• W1923790426 cites W2060117202 @default.
• W1923790426 cites W2065813445 @default.
• W1923790426 cites W2080173984 @default.
• W1923790426 cites W2094796108 @default.
• W1923790426 cites W2115144830 @default.
• W1923790426 cites W2117101293 @default.
• W1923790426 cites W2122371316 @default.
• W1923790426 cites W2129008615 @default.
• W1923790426 cites W2133162152 @default.
• W1923790426 cites W2160838897 @default.
• W1923790426 cites W2168731670 @default.
• W1923790426 cites W2178017422 @default.
• W1923790426 cites W586227194 @default.
• W1923790426 doi "https://doi.org/10.1523/jneurosci.10-05-01643.1990" @default.
• W1923790426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6570065" @default.
• W1923790426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2332802" @default.
• W1923790426 hasPublicationYear "1990" @default.
• W1923790426 type Work @default.
• W1923790426 sameAs 1923790426 @default.
• W1923790426 citedByCount "99" @default.
• W1923790426 countsByYear W19237904262012 @default.
• W1923790426 countsByYear W19237904262019 @default.
• W1923790426 countsByYear W19237904262021 @default.
• W1923790426 crossrefType "journal-article" @default.
• W1923790426 hasAuthorship W1923790426A5060332325 @default.
• W1923790426 hasAuthorship W1923790426A5080599051 @default.
• W1923790426 hasBestOaLocation W19237904261 @default.
• W1923790426 hasConcept C105702510 @default.
• W1923790426 hasConcept C118552586 @default.
• W1923790426 hasConcept C169760540 @default.
• W1923790426 hasConcept C203014093 @default.
• W1923790426 hasConcept C2776204877 @default.
• W1923790426 hasConcept C2776752467 @default.
• W1923790426 hasConcept C2776914184 @default.
• W1923790426 hasConcept C2778646069 @default.
• W1923790426 hasConcept C2779649809 @default.
• W1923790426 hasConcept C2779683492 @default.
• W1923790426 hasConcept C2779830541 @default.
• W1923790426 hasConcept C2780775167 @default.
• W1923790426 hasConcept C2781425419 @default.
• W1923790426 hasConcept C529278444 @default.
• W1923790426 hasConcept C70192387 @default.
• W1923790426 hasConcept C71924100 @default.
• W1923790426 hasConcept C86803240 @default.
• W1923790426 hasConceptScore W1923790426C105702510 @default.
• W1923790426 hasConceptScore W1923790426C118552586 @default.
• W1923790426 hasConceptScore W1923790426C169760540 @default.
• W1923790426 hasConceptScore W1923790426C203014093 @default.
• W1923790426 hasConceptScore W1923790426C2776204877 @default.
• W1923790426 hasConceptScore W1923790426C2776752467 @default.
• W1923790426 hasConceptScore W1923790426C2776914184 @default.
• W1923790426 hasConceptScore W1923790426C2778646069 @default.
• W1923790426 hasConceptScore W1923790426C2779649809 @default.
• W1923790426 hasConceptScore W1923790426C2779683492 @default.
• W1923790426 hasConceptScore W1923790426C2779830541 @default.
• W1923790426 hasConceptScore W1923790426C2780775167 @default.
• W1923790426 hasConceptScore W1923790426C2781425419 @default.
• W1923790426 hasConceptScore W1923790426C529278444 @default.
• W1923790426 hasConceptScore W1923790426C70192387 @default.
• W1923790426 hasConceptScore W1923790426C71924100 @default.
• W1923790426 hasConceptScore W1923790426C86803240 @default.
• W1923790426 hasIssue "5" @default.
• W1923790426 hasLocation W19237904261 @default.
• W1923790426 hasLocation W19237904262 @default.
• W1923790426 hasLocation W19237904263 @default.

• next