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• W192384915 abstract "Publisher Summary This chapter explores that before and after release of 24-hour unilateral (UUL) or bilateral ureteral ligation (BUL) in the dog, there is a sharp decrease in renal blood flow (RBF), with a highly significant intrarenal inward shifting of the reduced RBF. BUL relief leads to a phenomenon characterized by pronounced natriuresis and diuresis, usually designated as postobstructive diuresis (POD). Following the release of UUL, that is, in the presence of a normal contralateral kidney, POD is much less pronounced or does not occur at all. The modulatory role of renal prostaglandins (PGs) on renal circulation and their influence on sodium and water excretion is generally recognized and, at the same time, also debated. The pronounced inward shifting of intrarenal blood flow, associated with an augmented sodium and water excretion after release of UUL and BUL, leads to the assumption that enhanced production of endogenous PG might be responsible for renal functional changes during the postobstructive state. To test this assumption, intrarenal hemodynamic and excretory patterns are investigated by the radioactive microsphere and clearance techniques, both before and after release of UUL and BUL, while PG production is inhibited by the intravenous administration of indomethacin." @default.
• W192384915 created "2016-06-24" @default.
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• W192384915 date "1981-01-01" @default.
• W192384915 modified "2023-09-25" @default.
• W192384915 title "EFFECT OF INDOMETHACIN (IM) ON RENAL FUNCTION BEFORE AND AFTER RELEASE OF 24 HOURS UNILATERAL (UUL) AND BILATERAL (BUL) URETERAL LIGATION" @default.
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• W192384915 doi "https://doi.org/10.1016/b978-0-08-026824-8.50034-5" @default.
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