Matches in SemOpenAlex for { <https://semopenalex.org/work/W1923960858> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1923960858 endingPage "28" @default.
- W1923960858 startingPage "21" @default.
- W1923960858 abstract "Objective: To analyze the impacts of β-tubulin-III (TUBB3), thymidylate synthase (TS) and excision repair cross complementation group 1 (ERCC1) mRNA expressions on chemoresponse and clinical outcomes of patients with advanced gastric cancer (GC) treated with docetaxel (TXT)/cisplatin (CDDP)/fluorouracil (FU) (DCF) regimen chemotherapy. Methods: The study population consisted of 48 patients with advanced GC. All patients were treated with DCF regimen palliative chemotherapy. The mRNA expressions of TUBB3, TS and ERCC1 of primary tumors were examined by multiplex branched-DNA liquid chip technology. Results: The patients with low TUBB3 mRNA expression had significantly higher response rate to chemotherapy than patients with high TUBB3 expression (P=0.011). There were no significant differences between response rate and TS or ERCC1 expression pattern. Median overall survival (OS) and median time to progression (TTP) were significantly longer in patients with low TUBB3 mRNA expression (P=0.002, P<0.001). TS or ERCC1 expression was not correlated with TTP and OS. In the combined analysis including TUBB3, TS and ERCC1, the patients with 0 or 1 high expression gene had better response rate, TTP and OS than the remaining patients (all P<0.001). Multivariate analysis revealed that Eastern Cooperative Oncology Group (ECOG) ≥2 [hazard ratio (HR) =2.42, P=0.009] and TUBB3 (HR =2.34, P=0.036) mRNA expression significantly impacted on OS. Conclusions: High TUBB3 mRNA expression is correlated with resistance to DCF regimen chemotherapy. TUBB3 may be a predictive and prognostic factor in patients with advanced GC treated with TXT-based chemotherapy. The combined evaluation of TUBB3, TS and ERCC1 expression can promote the individual treatment in advanced GC." @default.
- W1923960858 created "2016-06-24" @default.
- W1923960858 creator A5029213312 @default.
- W1923960858 creator A5045919942 @default.
- W1923960858 creator A5054057323 @default.
- W1923960858 creator A5057974824 @default.
- W1923960858 creator A5071037763 @default.
- W1923960858 creator A5073608914 @default.
- W1923960858 date "2013-11-21" @default.
- W1923960858 modified "2023-09-24" @default.
- W1923960858 title "Effects of TUBB3, TS and ERCC1 mRNA expressions on chemoresponse and clinical outcome of advanced gastric cancer by multiplex branched-DNA liquid chip technology" @default.
- W1923960858 hasPublicationYear "2013" @default.
- W1923960858 type Work @default.
- W1923960858 sameAs 1923960858 @default.
- W1923960858 citedByCount "1" @default.
- W1923960858 countsByYear W19239608582013 @default.
- W1923960858 crossrefType "journal-article" @default.
- W1923960858 hasAuthorship W1923960858A5029213312 @default.
- W1923960858 hasAuthorship W1923960858A5045919942 @default.
- W1923960858 hasAuthorship W1923960858A5054057323 @default.
- W1923960858 hasAuthorship W1923960858A5057974824 @default.
- W1923960858 hasAuthorship W1923960858A5071037763 @default.
- W1923960858 hasAuthorship W1923960858A5073608914 @default.
- W1923960858 hasConcept C104317684 @default.
- W1923960858 hasConcept C104451858 @default.
- W1923960858 hasConcept C121608353 @default.
- W1923960858 hasConcept C123321153 @default.
- W1923960858 hasConcept C126322002 @default.
- W1923960858 hasConcept C134935766 @default.
- W1923960858 hasConcept C143998085 @default.
- W1923960858 hasConcept C207103383 @default.
- W1923960858 hasConcept C2776694085 @default.
- W1923960858 hasConcept C2778239845 @default.
- W1923960858 hasConcept C2779309665 @default.
- W1923960858 hasConcept C2780456651 @default.
- W1923960858 hasConcept C2781190966 @default.
- W1923960858 hasConcept C2781413609 @default.
- W1923960858 hasConcept C44249647 @default.
- W1923960858 hasConcept C55493867 @default.
- W1923960858 hasConcept C71924100 @default.
- W1923960858 hasConcept C86803240 @default.
- W1923960858 hasConcept C90924648 @default.
- W1923960858 hasConceptScore W1923960858C104317684 @default.
- W1923960858 hasConceptScore W1923960858C104451858 @default.
- W1923960858 hasConceptScore W1923960858C121608353 @default.
- W1923960858 hasConceptScore W1923960858C123321153 @default.
- W1923960858 hasConceptScore W1923960858C126322002 @default.
- W1923960858 hasConceptScore W1923960858C134935766 @default.
- W1923960858 hasConceptScore W1923960858C143998085 @default.
- W1923960858 hasConceptScore W1923960858C207103383 @default.
- W1923960858 hasConceptScore W1923960858C2776694085 @default.
- W1923960858 hasConceptScore W1923960858C2778239845 @default.
- W1923960858 hasConceptScore W1923960858C2779309665 @default.
- W1923960858 hasConceptScore W1923960858C2780456651 @default.
- W1923960858 hasConceptScore W1923960858C2781190966 @default.
- W1923960858 hasConceptScore W1923960858C2781413609 @default.
- W1923960858 hasConceptScore W1923960858C44249647 @default.
- W1923960858 hasConceptScore W1923960858C55493867 @default.
- W1923960858 hasConceptScore W1923960858C71924100 @default.
- W1923960858 hasConceptScore W1923960858C86803240 @default.
- W1923960858 hasConceptScore W1923960858C90924648 @default.
- W1923960858 hasIssue "1" @default.
- W1923960858 hasLocation W19239608581 @default.
- W1923960858 hasOpenAccess W1923960858 @default.
- W1923960858 hasPrimaryLocation W19239608581 @default.
- W1923960858 hasRelatedWork W1653063381 @default.
- W1923960858 hasRelatedWork W2023759187 @default.
- W1923960858 hasRelatedWork W2216742587 @default.
- W1923960858 hasRelatedWork W2347044900 @default.
- W1923960858 hasRelatedWork W2350857251 @default.
- W1923960858 hasRelatedWork W2351610415 @default.
- W1923960858 hasRelatedWork W2354474627 @default.
- W1923960858 hasRelatedWork W2355902061 @default.
- W1923960858 hasRelatedWork W2370590102 @default.
- W1923960858 hasRelatedWork W2374067113 @default.
- W1923960858 hasRelatedWork W2385816839 @default.
- W1923960858 hasRelatedWork W2386712866 @default.
- W1923960858 hasRelatedWork W2426130016 @default.
- W1923960858 hasRelatedWork W2460398187 @default.
- W1923960858 hasRelatedWork W2560435420 @default.
- W1923960858 hasRelatedWork W3028963668 @default.
- W1923960858 hasRelatedWork W3030799819 @default.
- W1923960858 hasRelatedWork W3031424072 @default.
- W1923960858 hasRelatedWork W3032803164 @default.
- W1923960858 hasRelatedWork W2329423762 @default.
- W1923960858 hasVolume "3" @default.
- W1923960858 isParatext "false" @default.
- W1923960858 isRetracted "false" @default.
- W1923960858 magId "1923960858" @default.
- W1923960858 workType "article" @default.