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• W1924025473 abstract "Molecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied.Morphological analysis showed MIP NPs of 20-50 nm; MIP NP exhibited high affinity and selectivity for the target analyte: low nanomolar Kds for the interaction NP/Hepcidin-25, but none for the NP/non regulative Hepcidin-20. The MIP NP were integrated as recognition element in SPR allowing the detection of Hepcidin-25 in 3 min. Linearity was observed with the logarithm of Hepcidin-25 concentration in the range 7.2-720 pM. LOD was 5 pM. The response for Hepcidin-20 was limited. Hepcidin-25 determination in real serum samples spiked with known analyte concentrations was also attempted.The integration of MIP NP to SPR allowed the determination of Hepcidin-25 at picomolar concentrations in short times outperforming the actual state of art. Optimization is still needed for real sample measurements in view of future clinical applications." @default.
• W1924025473 created "2016-06-24" @default.
• W1924025473 creator A5001214365 @default.
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• W1924025473 date "2015-08-27" @default.
• W1924025473 modified "2023-10-14" @default.
• W1924025473 title "Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25" @default.
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• W1924025473 doi "https://doi.org/10.1186/s12951-015-0115-3" @default.
• W1924025473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4549936" @default.
• W1924025473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26311037" @default.
• W1924025473 hasPublicationYear "2015" @default.
• W1924025473 type Work @default.
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