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- W1924062103 abstract "Spectral karyotyping (SKY) is a powerful 24-color, whole chromosome-painting assay allowing the visualization of each chromosome in one experiment. Subtle karyotype rearrangements can be detected easily so that small translocations lead to a transition from one color to another at the chromosomal breakpoint region. SKY has enabled the elucidation of several examples of hidden or cryptic structural aberrations that may otherwise have been left undetected by classical cytogenetic methods. Furthermore, the chromosomal origins of abnormalities once designated marker chromosomes can now be determined rather than left unidentified. SKY analysis of cancer cytogenetics samples provides a much more detailed description of the highly abnormal karyotypes that characterize advanced tumors and cancer cell lines. In addition, SKY significantly adds to the power of clinical cytogenetic analysis of constitutional chromosomal aberrations by facilitating the identification of subtle structural rearrangements that may contain aneuploidy with potential pathological consequences." @default.
- W1924062103 created "2016-06-24" @default.
- W1924062103 creator A5004696064 @default.
- W1924062103 creator A5062106369 @default.
- W1924062103 date "2001-02-01" @default.
- W1924062103 modified "2023-09-23" @default.
- W1924062103 title "Advances in the detection of chromosomal aberrations using spectral karyotyping" @default.
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- W1924062103 doi "https://doi.org/10.1034/j.1399-0004.2001.590201.x" @default.
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