FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924062135> ?p ?o ?g. }

• W1924062135 endingPage "3105" @default.
• W1924062135 startingPage "3095" @default.
• W1924062135 abstract "In adenovirus-infected cells, the epidermal growth factor receptor (EGF-R) is internalized from the cell surface via endosomes and is degraded, and the E3 10,400-dalton protein (10.4K protein) is required for this effect (C. R. Carlin, A. E. Tollefson, H. A. Brady, B. L. Hoffman, and W. S. M. Wold, Cell 57:135-144, 1989). We now report that both the E3 10.4K and E3 14.5K proteins are required for this down-regulation of EGF-R in adenovirus-infected cells. Down-regulation of cell surface EGF-R was demonstrated by results from several methods, namely the absence of EGF-R autophosphorylation in an immune complex kinase assay, the inability to iodinate EGF-R on the cell surface, the formation of endosomes containing EGF-R as detected by immunofluorescence, and the degradation of the metabolically [35S]Met-labeled fully processed 170K species of EGF-R. No effect on the initial synthesis of EGF-R was observed. This down-regulation was ascribed to the 10.4K and 14.5K proteins through the analysis of cells infected with rec700 (wild-type), dl748 (10.4K-, 14.5K+), or dl764 (10.4K+, 14.5K-) or coinfected with dl748 plus dl764. Further evidence that the 10.4K and 14.5K proteins function in concert was obtained by demonstrating that the 10.4K protein was coimmunoprecipitated with the 14.5K protein by using three different antisera to the 14.5K protein, strongly implying that the 10.4K and 14.5K proteins exist as a complex. Together, these results indicate that the 10.4K and 14.5K proteins function as a complex to stimulate endosome-mediated internalization and degradation of EGF-R in adenovirus-infected cells." @default.
• W1924062135 created "2016-06-24" @default.
• W1924062135 creator A5032387026 @default.
• W1924062135 creator A5053821060 @default.
• W1924062135 creator A5063522218 @default.
• W1924062135 creator A5067243488 @default.
• W1924062135 creator A5081236075 @default.
• W1924062135 date "1991-06-01" @default.
• W1924062135 modified "2023-09-27" @default.
• W1924062135 title "The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor" @default.
• W1924062135 cites W1036870626 @default.
• W1924062135 cites W1486479332 @default.
• W1924062135 cites W1506671456 @default.
• W1924062135 cites W1538995576 @default.
• W1924062135 cites W1542589563 @default.
• W1924062135 cites W1639892513 @default.
• W1924062135 cites W1779634392 @default.
• W1924062135 cites W1811411196 @default.
• W1924062135 cites W1829732864 @default.
• W1924062135 cites W1851805049 @default.
• W1924062135 cites W1963631969 @default.
• W1924062135 cites W1970516412 @default.
• W1924062135 cites W1976152540 @default.
• W1924062135 cites W1983303434 @default.
• W1924062135 cites W1987108079 @default.
• W1924062135 cites W1992045035 @default.
• W1924062135 cites W1997962608 @default.
• W1924062135 cites W2006733381 @default.
• W1924062135 cites W2019898590 @default.
• W1924062135 cites W2022821869 @default.
• W1924062135 cites W2024605512 @default.
• W1924062135 cites W2030955009 @default.
• W1924062135 cites W2032359283 @default.
• W1924062135 cites W2032422012 @default.
• W1924062135 cites W2033785962 @default.
• W1924062135 cites W2037871888 @default.
• W1924062135 cites W2049021232 @default.
• W1924062135 cites W2057261507 @default.
• W1924062135 cites W2066780628 @default.
• W1924062135 cites W2074582770 @default.
• W1924062135 cites W2079071516 @default.
• W1924062135 cites W2086093618 @default.
• W1924062135 cites W2091792783 @default.
• W1924062135 cites W2095549623 @default.
• W1924062135 cites W2102626689 @default.
• W1924062135 cites W2103174300 @default.
• W1924062135 cites W2113959082 @default.
• W1924062135 cites W2115668720 @default.
• W1924062135 cites W2126384008 @default.
• W1924062135 cites W2129732197 @default.
• W1924062135 cites W2142418281 @default.
• W1924062135 cites W2146998438 @default.
• W1924062135 cites W2153032671 @default.
• W1924062135 cites W2419354985 @default.
• W1924062135 cites W3140604265 @default.
• W1924062135 cites W97075052 @default.
• W1924062135 doi "https://doi.org/10.1128/jvi.65.6.3095-3105.1991" @default.
• W1924062135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/240965" @default.
• W1924062135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1851870" @default.
• W1924062135 hasPublicationYear "1991" @default.
• W1924062135 type Work @default.
• W1924062135 sameAs 1924062135 @default.
• W1924062135 citedByCount "96" @default.
• W1924062135 countsByYear W19240621352012 @default.
• W1924062135 countsByYear W19240621352013 @default.
• W1924062135 countsByYear W19240621352014 @default.
• W1924062135 countsByYear W19240621352019 @default.
• W1924062135 countsByYear W19240621352021 @default.
• W1924062135 crossrefType "journal-article" @default.
• W1924062135 hasAuthorship W1924062135A5032387026 @default.
• W1924062135 hasAuthorship W1924062135A5053821060 @default.
• W1924062135 hasAuthorship W1924062135A5063522218 @default.
• W1924062135 hasAuthorship W1924062135A5067243488 @default.
• W1924062135 hasAuthorship W1924062135A5081236075 @default.
• W1924062135 hasBestOaLocation W19240621351 @default.
• W1924062135 hasConcept C102747710 @default.
• W1924062135 hasConcept C150109051 @default.
• W1924062135 hasConcept C153911025 @default.
• W1924062135 hasConcept C170493617 @default.
• W1924062135 hasConcept C184235292 @default.
• W1924062135 hasConcept C2776362946 @default.
• W1924062135 hasConcept C2779438470 @default.
• W1924062135 hasConcept C55493867 @default.
• W1924062135 hasConcept C86803240 @default.
• W1924062135 hasConcept C95444343 @default.
• W1924062135 hasConcept C97029542 @default.
• W1924062135 hasConceptScore W1924062135C102747710 @default.
• W1924062135 hasConceptScore W1924062135C150109051 @default.
• W1924062135 hasConceptScore W1924062135C153911025 @default.
• W1924062135 hasConceptScore W1924062135C170493617 @default.
• W1924062135 hasConceptScore W1924062135C184235292 @default.
• W1924062135 hasConceptScore W1924062135C2776362946 @default.
• W1924062135 hasConceptScore W1924062135C2779438470 @default.
• W1924062135 hasConceptScore W1924062135C55493867 @default.
• W1924062135 hasConceptScore W1924062135C86803240 @default.
• W1924062135 hasConceptScore W1924062135C95444343 @default.
• W1924062135 hasConceptScore W1924062135C97029542 @default.
• W1924062135 hasIssue "6" @default.

• next