Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924100832> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1924100832 endingPage "726" @default.
- W1924100832 startingPage "721" @default.
- W1924100832 abstract "A sensitive and selective ultra fast liquid chromatography (UFLC) method has been developed and validated for the determination of a potent and novel antitubercular compound S006‐830 in Sprague Dawley (SD) rat plasma. Samples were extracted and processed by protein precipitation method using acetonitrile. Chromatographic separation was achieved on a Phenomenex, Luna C‐18 column (3μm, 100mm x 2mm i.d.) under isocratic condition. Detection was performed on UFLC‐NEXERA system (LC‐30AD, Shimadzu, Kyoto, Japan) with a degasser (DGU‐20A), auto‐injector (SIL‐30AC), fixed with a 100‐μL loop. Method was found sensitive and reproducible over a linearity range of 15.6‐2000 ng/mL. Recovery of S006‐830 and internal standard was found >90% for spiked matrix control and standard quality control plasma samples. This validated method was successfully applied to generate pharmacokinetic profile of S006‐830 in SD rats. Oral dose proportionality studies were conducted at 100, 50, 25 mg/Kg dose levels, while an IV study was conducted at 25 mg/Kg dose. There was dose dependent increase in AUC and C max indicating S006‐830 to exhibit linear pharmacokinetics. S006‐830 exhibited favorable bioavailability in the range of 45‐55%. Copyright © 2014 John Wiley & Sons, Ltd." @default.
- W1924100832 created "2016-06-24" @default.
- W1924100832 creator A5004135662 @default.
- W1924100832 creator A5018532425 @default.
- W1924100832 creator A5034193111 @default.
- W1924100832 creator A5065498407 @default.
- W1924100832 creator A5075175055 @default.
- W1924100832 creator A5082426175 @default.
- W1924100832 creator A5085374287 @default.
- W1924100832 date "2014-11-20" @default.
- W1924100832 modified "2023-10-16" @default.
- W1924100832 title "UFLC method development and validation of a novel triethylamine containing thiophene S006-830 - an antitubercular molecule and its application to pharmacokinetic and bioavailability studies in SD rats" @default.
- W1924100832 cites W1520838229 @default.
- W1924100832 cites W1984116181 @default.
- W1924100832 cites W2070301035 @default.
- W1924100832 cites W2123023822 @default.
- W1924100832 cites W2131255031 @default.
- W1924100832 cites W2135070766 @default.
- W1924100832 cites W2158071964 @default.
- W1924100832 cites W2158409385 @default.
- W1924100832 doi "https://doi.org/10.1002/dta.1748" @default.
- W1924100832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25412830" @default.
- W1924100832 hasPublicationYear "2014" @default.
- W1924100832 type Work @default.
- W1924100832 sameAs 1924100832 @default.
- W1924100832 citedByCount "5" @default.
- W1924100832 countsByYear W19241008322016 @default.
- W1924100832 countsByYear W19241008322017 @default.
- W1924100832 countsByYear W19241008322022 @default.
- W1924100832 crossrefType "journal-article" @default.
- W1924100832 hasAuthorship W1924100832A5004135662 @default.
- W1924100832 hasAuthorship W1924100832A5018532425 @default.
- W1924100832 hasAuthorship W1924100832A5034193111 @default.
- W1924100832 hasAuthorship W1924100832A5065498407 @default.
- W1924100832 hasAuthorship W1924100832A5075175055 @default.
- W1924100832 hasAuthorship W1924100832A5082426175 @default.
- W1924100832 hasAuthorship W1924100832A5085374287 @default.
- W1924100832 hasConcept C112705442 @default.
- W1924100832 hasConcept C137535248 @default.
- W1924100832 hasConcept C178790620 @default.
- W1924100832 hasConcept C179998833 @default.
- W1924100832 hasConcept C181389837 @default.
- W1924100832 hasConcept C185592680 @default.
- W1924100832 hasConcept C2781283055 @default.
- W1924100832 hasConcept C42404028 @default.
- W1924100832 hasConcept C43617362 @default.
- W1924100832 hasConcept C71924100 @default.
- W1924100832 hasConcept C74774607 @default.
- W1924100832 hasConcept C98274493 @default.
- W1924100832 hasConceptScore W1924100832C112705442 @default.
- W1924100832 hasConceptScore W1924100832C137535248 @default.
- W1924100832 hasConceptScore W1924100832C178790620 @default.
- W1924100832 hasConceptScore W1924100832C179998833 @default.
- W1924100832 hasConceptScore W1924100832C181389837 @default.
- W1924100832 hasConceptScore W1924100832C185592680 @default.
- W1924100832 hasConceptScore W1924100832C2781283055 @default.
- W1924100832 hasConceptScore W1924100832C42404028 @default.
- W1924100832 hasConceptScore W1924100832C43617362 @default.
- W1924100832 hasConceptScore W1924100832C71924100 @default.
- W1924100832 hasConceptScore W1924100832C74774607 @default.
- W1924100832 hasConceptScore W1924100832C98274493 @default.
- W1924100832 hasIssue "8" @default.
- W1924100832 hasLocation W19241008321 @default.
- W1924100832 hasLocation W19241008322 @default.
- W1924100832 hasOpenAccess W1924100832 @default.
- W1924100832 hasPrimaryLocation W19241008321 @default.
- W1924100832 hasRelatedWork W1964203865 @default.
- W1924100832 hasRelatedWork W2000780459 @default.
- W1924100832 hasRelatedWork W2018887812 @default.
- W1924100832 hasRelatedWork W2019919776 @default.
- W1924100832 hasRelatedWork W2060521843 @default.
- W1924100832 hasRelatedWork W2072694519 @default.
- W1924100832 hasRelatedWork W2185025379 @default.
- W1924100832 hasRelatedWork W2905128512 @default.
- W1924100832 hasRelatedWork W3037891356 @default.
- W1924100832 hasRelatedWork W3161069647 @default.
- W1924100832 hasVolume "7" @default.
- W1924100832 isParatext "false" @default.
- W1924100832 isRetracted "false" @default.
- W1924100832 magId "1924100832" @default.
- W1924100832 workType "article" @default.