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• W1924215734 endingPage "3130" @default.
• W1924215734 startingPage "3119" @default.
• W1924215734 abstract "It is well known that immune responses in the intestine remain in a state of controlled inflammation, suggesting that not only active suppression by regulatory T cells plays an important role in the normal intestinal homeostasis, but also its dysregulation leads to the development of inflammatory bowel disease. In this study, we demonstrate that the CD4(+)CD25(bright) T cells reside in the human intestinal lamina propria (LP) and functionally retain regulatory activities. All human LP CD4(+) T cells regardless of CD25 expression constitutively expressed CTLA-4, glucocorticoid-induced TNFR family-related protein, and Foxp3 and proliferate poorly. Although LP CD4(+)CD25(-) T cells showed an activated and anergic/memory phenotype, they did not retain regulatory activity. In LP CD4(+)CD25(+) T cells, however, cells expressing CD25 at high levels (CD4(+)CD25(bright)) suppressed the proliferation and various cytokine productions of CD4(+)CD25(-) T cells. LP CD4(+)CD25(bright) T cells by themselves produced fewer amounts of IL-2, IFN-gamma, and IL-10. Interestingly, LP CD4(+)CD25(bright) T cells with regulatory T activity were significantly increased in patients with active inflammatory bowel disease. These results suggest that CD4(+)CD25(bright) T cells found in the normal and inflamed intestinal mucosa selectively inhibit the host immune response and therefore may contribute to the intestinal immune homeostasis." @default.
• W1924215734 created "2016-06-24" @default.
• W1924215734 creator A5027680971 @default.
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• W1924215734 date "2004-09-01" @default.
• W1924215734 modified "2023-10-13" @default.
• W1924215734 title "CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells" @default.
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• W1924215734 doi "https://doi.org/10.4049/jimmunol.173.5.3119" @default.
• W1924215734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15322172" @default.
• W1924215734 hasPublicationYear "2004" @default.
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