FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924454674> ?p ?o ?g. }

• W1924454674 abstract "The 26S proteasome is a promising new target for breast cancer therapy. The degradation of proteins by the proteasome is an essential metabolic process, and inhibition of the proteasome results in cell-cycle arrest and apoptosis. However, cancer cells and proliferating blood vessels appear to be particularly sensitive to the effects of proteasome inhibition. Studies carried out in breast cancer cells and murine xenograft models of breast cancer have demonstrated the potent antitumor effects of proteasome inhibition in this disease. Proteasome inhibition interferes with many cell signaling pathways, including those involved in the development and progression of breast cancer. The potent and selective proteasome inhibitor bortezomib (VELCADE; formerly known as PS-341) is particularly promising as a potential anticancer agent. PS-341 is the first proteasome inhibitor to be extensively studied in murine models of cancer and to progress to clinical trials in cancer patients. Preliminary clinical data from patients with a range of malignancies indicate that the drug effectively inhibits proteasome activity at doses associated with manageable toxicity. Early clinical trials are currently recruiting participants for the analysis of PS-341 activity in breast cancer." @default.
• W1924454674 created "2016-06-24" @default.
• W1924454674 creator A5013437930 @default.
• W1924454674 date "2002-06-01" @default.
• W1924454674 modified "2023-09-28" @default.
• W1924454674 title "The Proteasome as a Novel Target for the Treatment of Breast Cancer1" @default.
• W1924454674 cites W1549880413 @default.
• W1924454674 cites W1554632349 @default.
• W1924454674 cites W1555786525 @default.
• W1924454674 cites W1594617739 @default.
• W1924454674 cites W1832030339 @default.
• W1924454674 cites W1838166837 @default.
• W1924454674 cites W1894416004 @default.
• W1924454674 cites W1954278762 @default.
• W1924454674 cites W1968330653 @default.
• W1924454674 cites W1970235416 @default.
• W1924454674 cites W1973596168 @default.
• W1924454674 cites W1974178581 @default.
• W1924454674 cites W1976582166 @default.
• W1924454674 cites W1982332661 @default.
• W1924454674 cites W1983398917 @default.
• W1924454674 cites W1992978957 @default.
• W1924454674 cites W1995533869 @default.
• W1924454674 cites W1998246524 @default.
• W1924454674 cites W2008744347 @default.
• W1924454674 cites W2009410162 @default.
• W1924454674 cites W2013339424 @default.
• W1924454674 cites W2013809140 @default.
• W1924454674 cites W2018397818 @default.
• W1924454674 cites W2026158949 @default.
• W1924454674 cites W2029276835 @default.
• W1924454674 cites W2039422688 @default.
• W1924454674 cites W2040202840 @default.
• W1924454674 cites W2040762618 @default.
• W1924454674 cites W2050018101 @default.
• W1924454674 cites W2051994734 @default.
• W1924454674 cites W2054174954 @default.
• W1924454674 cites W2056769035 @default.
• W1924454674 cites W2058858378 @default.
• W1924454674 cites W2064201629 @default.
• W1924454674 cites W2064627520 @default.
• W1924454674 cites W2066284211 @default.
• W1924454674 cites W2067233094 @default.
• W1924454674 cites W2067530043 @default.
• W1924454674 cites W2068696470 @default.
• W1924454674 cites W2083308557 @default.
• W1924454674 cites W2086964878 @default.
• W1924454674 cites W2089687291 @default.
• W1924454674 cites W2090379314 @default.
• W1924454674 cites W2102714295 @default.
• W1924454674 cites W2112825652 @default.
• W1924454674 cites W2115732428 @default.
• W1924454674 cites W2117184453 @default.
• W1924454674 cites W2118617212 @default.
• W1924454674 cites W2120760156 @default.
• W1924454674 cites W2121239154 @default.
• W1924454674 cites W2126350892 @default.
• W1924454674 cites W2134791874 @default.
• W1924454674 cites W2137651777 @default.
• W1924454674 cites W2138077682 @default.
• W1924454674 cites W2147730379 @default.
• W1924454674 cites W2147760686 @default.
• W1924454674 cites W2148131050 @default.
• W1924454674 cites W2148975776 @default.
• W1924454674 cites W2151458137 @default.
• W1924454674 cites W2156320654 @default.
• W1924454674 cites W2158069617 @default.
• W1924454674 cites W2158708535 @default.
• W1924454674 cites W2159831275 @default.
• W1924454674 cites W2164710551 @default.
• W1924454674 cites W2169724245 @default.
• W1924454674 cites W2171865516 @default.
• W1924454674 cites W2176931134 @default.
• W1924454674 cites W2288500425 @default.
• W1924454674 cites W2315880968 @default.
• W1924454674 cites W2330374913 @default.
• W1924454674 cites W2335735158 @default.
• W1924454674 cites W2409672023 @default.
• W1924454674 cites W2475150687 @default.
• W1924454674 doi "https://doi.org/10.3233/bd-2002-15107" @default.
• W1924454674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15687646" @default.
• W1924454674 hasPublicationYear "2002" @default.
• W1924454674 type Work @default.
• W1924454674 sameAs 1924454674 @default.
• W1924454674 citedByCount "15" @default.
• W1924454674 countsByYear W19244546742012 @default.
• W1924454674 countsByYear W19244546742013 @default.
• W1924454674 countsByYear W19244546742014 @default.
• W1924454674 countsByYear W19244546742016 @default.
• W1924454674 countsByYear W19244546742017 @default.
• W1924454674 countsByYear W19244546742019 @default.
• W1924454674 countsByYear W19244546742020 @default.
• W1924454674 countsByYear W19244546742021 @default.
• W1924454674 crossrefType "journal-article" @default.
• W1924454674 hasAuthorship W1924454674A5013437930 @default.
• W1924454674 hasConcept C121608353 @default.
• W1924454674 hasConcept C126322002 @default.
• W1924454674 hasConcept C27740335 @default.
• W1924454674 hasConcept C2776148510 @default.
• W1924454674 hasConcept C2776364478 @default.

• next