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• W1924638511 abstract "Most bacteria synthesize muramyl-pentapeptide peptidoglycan precursors ending with a D-alanyl residue (e.g., UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala). However, it was recently demonstrated that other types of precursors, notably D-lactate-ending molecules, could be synthesized by several lactic acid bacteria. This particular feature leads to vancomycin resistance. Vancomycin is a glycopeptide antibiotic that blocks cell wall synthesis by the formation of a complex with the extremity of peptidoglycan precursors. Substitution of the terminal D-alanine by D-lactate reduces the affinity of the antibiotic for its target. Lactobacillus plantarum is a lactic acid bacterium naturally resistant to vancomycin. It converts most of the glycolytic pyruvate to L- and D-lactate by using stereospecific enzymes designated L- and D-lactate dehydrogenases, respectively. In the present study, we show that L. plantarum actually synthesizes D-lactate-ending peptidoglycan precursors. We also report the construction of a strain which is deficient for both D- and L-lactate dehydrogenase activities and which produces only trace amounts of D- and L-lactate. As a consequence, the peptidoglycan synthesis pathway is drastically affected. The wild-type precursor is still present, but a new type of D-alanine-ending precursor is also synthesized in large quantities, which results in a highly enhanced sensitivity to vancomycin." @default.
• W1924638511 created "2016-06-24" @default.
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• W1924638511 date "1996-09-01" @default.
• W1924638511 modified "2023-10-17" @default.
• W1924638511 title "Knockout of the two ldh genes has a major impact on peptidoglycan precursor synthesis in Lactobacillus plantarum" @default.
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• W1924638511 doi "https://doi.org/10.1128/jb.178.18.5431-5437.1996" @default.
• W1924638511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/178362" @default.
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