Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924715985> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1924715985 endingPage "1353" @default.
- W1924715985 startingPage "1343" @default.
- W1924715985 abstract "gamma-Aminobutyric acid (GABA) is the proposed neurotransmitter for four types of cerebellar neurons-Purkinje, Golgi, basket, and stellate neurons. With this investigation we have begun studies to establish when these neurons acquire their neurotransmitter “identification.” Autoradiographic studies of both cultured embryonic (embryonic day 13) cerebellar cells and of intact embryonic cerebellum (embryonic day 13) were conducted with tritiated GABA. Two to 5% of the embryonic cerebellar cells accumulated [3H]GABA in vitro. By morphological and immunocytochemical criteria, labeled cells were large neurons with either a thick, apical process, a multipolar shape, or were bipolar with longer processes. The identification of cells which accumulated [3H]GABA as neuronal precursors was supported by the differential sensitivity to drugs that preferentially inhibit accumulation of [3H]GABA by neurons and glia. The results of the in vitro experiments were confirmed and extended with in vivo experiments. When intact cerebellar tissue was removed at embryonic day 13, stripped of meninges and choroid plexus, exposed to low concentrations of [3H]GABA, and processed for light microscopic autoradiography, heavily labeled cells were seen in the middle of the cerebellar anlage. Labeled cells were not seen in the ventricular zone of proliferating neuroblasts lining the fourth ventricle or in the external granular layer emerging at the lateral aspect of the pial surface. The accumulation of [3H]GABA by these cells also showed the pharmacological characteristics of uptake by neurons. This study shows that among migrating, immature forms of the larger neurons of the embryonic cerebellum, there is a select group which accumulates [3H]GABA and other classes of cells which do not. These results indicate very early acquisition of transmitter expression by cerebellar neurons, far in advance of their final positioning and establishment of synapses." @default.
- W1924715985 created "2016-06-24" @default.
- W1924715985 creator A5025501952 @default.
- W1924715985 creator A5060330868 @default.
- W1924715985 creator A5074167215 @default.
- W1924715985 creator A5079364280 @default.
- W1924715985 date "1984-05-01" @default.
- W1924715985 modified "2023-09-27" @default.
- W1924715985 title "Embryonic cerebellar neurons accumulate [3H]-gamma-aminobutyric acid: visualization of developing gamma-aminobutyric acid-utilizing neurons in vitro and in vivo" @default.
- W1924715985 doi "https://doi.org/10.1523/jneurosci.04-05-01343.1984" @default.
- W1924715985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6564938" @default.
- W1924715985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6726335" @default.
- W1924715985 hasPublicationYear "1984" @default.
- W1924715985 type Work @default.
- W1924715985 sameAs 1924715985 @default.
- W1924715985 citedByCount "32" @default.
- W1924715985 countsByYear W19247159852013 @default.
- W1924715985 countsByYear W19247159852014 @default.
- W1924715985 crossrefType "journal-article" @default.
- W1924715985 hasAuthorship W1924715985A5025501952 @default.
- W1924715985 hasAuthorship W1924715985A5060330868 @default.
- W1924715985 hasAuthorship W1924715985A5074167215 @default.
- W1924715985 hasAuthorship W1924715985A5079364280 @default.
- W1924715985 hasBestOaLocation W19247159851 @default.
- W1924715985 hasConcept C104317684 @default.
- W1924715985 hasConcept C145103041 @default.
- W1924715985 hasConcept C150903083 @default.
- W1924715985 hasConcept C169760540 @default.
- W1924715985 hasConcept C170493617 @default.
- W1924715985 hasConcept C207001950 @default.
- W1924715985 hasConcept C2776219046 @default.
- W1924715985 hasConcept C2777771985 @default.
- W1924715985 hasConcept C2779652256 @default.
- W1924715985 hasConcept C529278444 @default.
- W1924715985 hasConcept C55493867 @default.
- W1924715985 hasConcept C86803240 @default.
- W1924715985 hasConcept C95444343 @default.
- W1924715985 hasConceptScore W1924715985C104317684 @default.
- W1924715985 hasConceptScore W1924715985C145103041 @default.
- W1924715985 hasConceptScore W1924715985C150903083 @default.
- W1924715985 hasConceptScore W1924715985C169760540 @default.
- W1924715985 hasConceptScore W1924715985C170493617 @default.
- W1924715985 hasConceptScore W1924715985C207001950 @default.
- W1924715985 hasConceptScore W1924715985C2776219046 @default.
- W1924715985 hasConceptScore W1924715985C2777771985 @default.
- W1924715985 hasConceptScore W1924715985C2779652256 @default.
- W1924715985 hasConceptScore W1924715985C529278444 @default.
- W1924715985 hasConceptScore W1924715985C55493867 @default.
- W1924715985 hasConceptScore W1924715985C86803240 @default.
- W1924715985 hasConceptScore W1924715985C95444343 @default.
- W1924715985 hasIssue "5" @default.
- W1924715985 hasLocation W19247159851 @default.
- W1924715985 hasLocation W19247159852 @default.
- W1924715985 hasLocation W19247159853 @default.
- W1924715985 hasLocation W19247159854 @default.
- W1924715985 hasOpenAccess W1924715985 @default.
- W1924715985 hasPrimaryLocation W19247159851 @default.
- W1924715985 hasRelatedWork W1426763493 @default.
- W1924715985 hasRelatedWork W1924715985 @default.
- W1924715985 hasRelatedWork W2038447984 @default.
- W1924715985 hasRelatedWork W2074896395 @default.
- W1924715985 hasRelatedWork W2075721460 @default.
- W1924715985 hasRelatedWork W2104648537 @default.
- W1924715985 hasRelatedWork W2473284317 @default.
- W1924715985 hasRelatedWork W2790039720 @default.
- W1924715985 hasRelatedWork W3114471381 @default.
- W1924715985 hasRelatedWork W4250501176 @default.
- W1924715985 hasVolume "4" @default.
- W1924715985 isParatext "false" @default.
- W1924715985 isRetracted "false" @default.
- W1924715985 magId "1924715985" @default.
- W1924715985 workType "article" @default.