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- W1924762808 endingPage "102" @default.
- W1924762808 startingPage "85" @default.
- W1924762808 abstract "Resistance to anticancer drugs is a complex process that results from alterations in drug targets; development of alternative pathways for growth activation; changes in cellular pharmacology, including increased drug efflux; regulatory changes that alter differentiation pathways or pathways for response to environmental adversity; and/or changes in the local physiology of the cancer, such as blood supply, tissue hydrodynamics, behavior of neighboring cells, and immune system response. All of these specific mechanisms are facilitated by the intrinsic hallmarks of cancer, such as tumor cell heterogeneity, redundancy of growth-promoting pathways, increased mutation rate and/or epigenetic alterations, and the dynamic variation of tumor behavior in time and space. Understanding the relative contribution of each of these factors is further complicated by the lack of adequate in vitro models that mimic clinical cancers. Several strategies to use current knowledge of drug resistance to improve treatment of cancer are suggested." @default.
- W1924762808 created "2016-06-24" @default.
- W1924762808 creator A5014421948 @default.
- W1924762808 creator A5022924056 @default.
- W1924762808 creator A5030334751 @default.
- W1924762808 creator A5039988058 @default.
- W1924762808 date "2016-01-06" @default.
- W1924762808 modified "2023-10-09" @default.
- W1924762808 title "Toward a Better Understanding of the Complexity of Cancer Drug Resistance" @default.
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