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• W1924830897 abstract "OBJECTIVE/BACKGROUND:Structural MRI allows to capture disease related structural changes beyond hippocampal atrophy. This study aimed to determine whether measures of regional sulcal morphology improve the diagnosis of early Alzheimer’s disease (AD) compared to the measure of hippocampal volume alone.DESIGN/METHOD:30 patients with mild cognitive impairment due to AD (MCI-AD) and 20 dementia-AD, all with confirmation of AD (cerebrospinal fluid AD biomarkers and amyloid imaging by PIB-PET) were compared to 30 controls with negative PIB-PET. For each subject, an automated method (BrainVisa) was used to calculate sulcal morphology in the whole brain, providing individual data on sulcal width and cortical thickness. We grouped the sulci in 18 regions of interests (ROI) according to AD neuropathological knowledge. Hippocampal volumes (HV) were segmented with an automated method (SACHA). Classification accuracy was assessed for sulci characteristics in each ROI and then in combination with hippocampal volume.RESULTS :The area under the ROC curves revealed that the cortical thickness around the rhinal sulcus and the HV, followed by the sulcal width and cortical thickness in temporo-parietal areas were the best markers for distinguishing MCI-AD from controls (p<0,001). A logistic regression model showed that adding the cortical thickness of the rhinal sulcus to the HV increased the classification score from 75 % for HV alone to 85% for the combined model. Similarly, combined measures of HV and intraparietal sulcus width raised the classification score to 83%.For dementia-AD diagnosis, the best markers were the cortical thickness around the temporal sulci, followed by the HV (p<0,001). The best diagnostic classification was obtained by combining the HV with cortical thickness of the inferior temporal sulcus (from 84 to 90%).CONCLUSION: Combining a sulcal morphological marker and hippocampal volume improved the diagnosis of early AD. Further studies in larger cohorts are necessary to define optimal individual cut-offs.FUNDING :ANR (grant number ANR-07-LVIE-002-0), PHRC 2010, Roche, “Investissement d’avenir”(grant number ANR-10-IAIHU-06), Fondation pour la Recherche Medicale Disclosure: Dr. Hamelin has nothing to disclose. Dr. Leonardo has nothing to disclose. Dr. Corlier has nothing to disclose. Dr. Corne has nothing to disclose. Dr. Chupin has nothing to disclose. Dr. Dubois has received personal compensation for activities with Eli Lilly & Co. and Roche Diagnostics Corp. Dr. Bottlaender has nothing to disclose. Dr. Colliot has received personal compensation for activities with Lundbeck Research USA, Inc., and Guerbet. Dr. Sarazin has received personal compensation for activities with Novartis, and Allianz as a speaker." @default.
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• W1924830897 date "2014-04-08" @default.
• W1924830897 modified "2023-10-18" @default.
• W1924830897 title "Improved Accuracy of the Diagnosis of Early Alzheimer’s Disease Using Combined Measures of Hippocampal Volume and Sulcal Morphology (P4.016)" @default.
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