FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924888045> ?p ?o ?g. }

• W1924888045 endingPage "3281" @default.
• W1924888045 startingPage "3269" @default.
• W1924888045 abstract "Chemosensory neuron diversity in C. elegans arises from the action of transcription factors that specify different aspects of sensory neuron fate. In the AWB and AWA olfactory neurons, the LIM homeobox gene lim-4 and the nuclear hormone receptor gene odr-7 are required to confer AWB and AWA-specific characteristics respectively, and to repress an AWC olfactory neuron-like default fate. Here, we show that AWA neuron fate is also regulated by a member of the LIM homeobox gene family, lin-11. lin-11 regulates AWA olfactory neuron differentiation by initiating expression of odr-7, which then autoregulates to maintain expression. lin-11 also regulates the fate of the ASG chemosensory neurons, which are the lineal sisters of the AWA neurons. We show that lin-11 is expressed dynamically in the AWA and ASG neurons, and that misexpression of lin-11 is sufficient to promote an ASG, but not an AWA fate, in a subset of neuron types. Our results suggest that differential temporal regulation of lin-11, presumably together with its interaction with asymmetrically segregated factors, results in the generation of the distinct AWA and ASG sensory neuron types. We propose that a LIM code may be an important contributor to the generation of functional diversity in a subset of olfactory and chemosensory neurons in C. elegans." @default.
• W1924888045 created "2016-06-24" @default.
• W1924888045 creator A5012857095 @default.
• W1924888045 creator A5041472770 @default.
• W1924888045 creator A5061513487 @default.
• W1924888045 creator A5063537699 @default.
• W1924888045 date "2001-09-01" @default.
• W1924888045 modified "2023-10-10" @default.
• W1924888045 title "The<i>lin-11</i>LIM homeobox gene specifies olfactory and chemosensory neuron fates in<i>C. elegans</i>" @default.
• W1924888045 cites W1544900705 @default.
• W1924888045 cites W1554974851 @default.
• W1924888045 cites W1836139622 @default.
• W1924888045 cites W1904905451 @default.
• W1924888045 cites W1944127002 @default.
• W1924888045 cites W1946787458 @default.
• W1924888045 cites W1949783943 @default.
• W1924888045 cites W1969067601 @default.
• W1924888045 cites W1969862105 @default.
• W1924888045 cites W1972201383 @default.
• W1924888045 cites W1977350867 @default.
• W1924888045 cites W1982630660 @default.
• W1924888045 cites W1983486478 @default.
• W1924888045 cites W1984174621 @default.
• W1924888045 cites W1985602726 @default.
• W1924888045 cites W1985962316 @default.
• W1924888045 cites W1989952069 @default.
• W1924888045 cites W1991777044 @default.
• W1924888045 cites W1993588490 @default.
• W1924888045 cites W1996364691 @default.
• W1924888045 cites W1996839811 @default.
• W1924888045 cites W2000814069 @default.
• W1924888045 cites W2004026630 @default.
• W1924888045 cites W2004945062 @default.
• W1924888045 cites W2006130293 @default.
• W1924888045 cites W2007755249 @default.
• W1924888045 cites W2008290466 @default.
• W1924888045 cites W2009266803 @default.
• W1924888045 cites W2011115644 @default.
• W1924888045 cites W2011389479 @default.
• W1924888045 cites W2011932029 @default.
• W1924888045 cites W2022221238 @default.
• W1924888045 cites W2025142458 @default.
• W1924888045 cites W2032881439 @default.
• W1924888045 cites W2033525251 @default.
• W1924888045 cites W2035904218 @default.
• W1924888045 cites W2039125865 @default.
• W1924888045 cites W2042489256 @default.
• W1924888045 cites W2047528119 @default.
• W1924888045 cites W2051440844 @default.
• W1924888045 cites W2053614178 @default.
• W1924888045 cites W2054712073 @default.
• W1924888045 cites W2056328047 @default.
• W1924888045 cites W2057104531 @default.
• W1924888045 cites W2061491095 @default.
• W1924888045 cites W2064416689 @default.
• W1924888045 cites W2064913148 @default.
• W1924888045 cites W2069592072 @default.
• W1924888045 cites W2070533417 @default.
• W1924888045 cites W2072248036 @default.
• W1924888045 cites W2079977851 @default.
• W1924888045 cites W2081079546 @default.
• W1924888045 cites W2082246779 @default.
• W1924888045 cites W2082421546 @default.
• W1924888045 cites W2089193539 @default.
• W1924888045 cites W2089827948 @default.
• W1924888045 cites W2089885047 @default.
• W1924888045 cites W2092502264 @default.
• W1924888045 cites W2094798191 @default.
• W1924888045 cites W2099763381 @default.
• W1924888045 cites W2110492953 @default.
• W1924888045 cites W2113585283 @default.
• W1924888045 cites W2117532375 @default.
• W1924888045 cites W2118509956 @default.
• W1924888045 cites W2119646657 @default.
• W1924888045 cites W2121039111 @default.
• W1924888045 cites W2128749538 @default.
• W1924888045 cites W2133831748 @default.
• W1924888045 cites W2138304761 @default.
• W1924888045 cites W2148211715 @default.
• W1924888045 cites W2148659320 @default.
• W1924888045 cites W2153800196 @default.
• W1924888045 cites W2164959082 @default.
• W1924888045 cites W2166978016 @default.
• W1924888045 cites W2171775558 @default.
• W1924888045 cites W2175075441 @default.
• W1924888045 cites W2182687083 @default.
• W1924888045 cites W2187425347 @default.
• W1924888045 cites W2279474202 @default.
• W1924888045 cites W2335952796 @default.
• W1924888045 cites W4234544185 @default.
• W1924888045 cites W4247636514 @default.
• W1924888045 cites W4297832928 @default.
• W1924888045 doi "https://doi.org/10.1242/dev.128.17.3269" @default.
• W1924888045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11546744" @default.
• W1924888045 hasPublicationYear "2001" @default.
• W1924888045 type Work @default.
• W1924888045 sameAs 1924888045 @default.
• W1924888045 citedByCount "80" @default.

• next