FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1924974311> ?p ?o ?g. }

• W1924974311 endingPage "1121" @default.
• W1924974311 startingPage "1115" @default.
• W1924974311 abstract "ABSTRACT Reliable quantification of gene and protein expression has potential to contribute significantly to the characterization of hypothesized modes of action (MOA) or adverse outcome pathways for critical effects of toxicants. Quantitative analysis of gene expression by benchmark dose (BMD) modeling has been facilitated by the development of effective software tools. In contrast, protein expression is still generally quantified by a less robust effect level (no or lowest [adverse] effect levels) approach, which minimizes its potential utility in the consideration of dose–response and temporal concordance for key events in hypothesized MOAs. BMD modeling is applied here to toxicological data on testicular toxicity to investigate its potential utility in analyzing protein expression relevant to the proposed MOA to inform human health risk assessment. The results illustrate how the BMD analysis of protein expression in animal tissues in response to toxicant exposure: (1) complements other toxicity data, and (2) contributes to consideration of the empirical concordance of dose–response relationships, as part of the weight of evidence for hypothesized MOAs to facilitate consideration and application in regulatory risk assessment. Lack of BMD analysis in proteomics has likely limited its use for these purposes. This paper illustrates the added value of BMD modeling to support and strengthen hypothetical MOAs as a basis to facilitate the translation and uptake of the results of proteomic research into risk assessment. Copyright © 2014 Her Majesty the Queen in Right of Canada. Journal of Applied Toxicology © 2014 John Wiley & Sons, Ltd." @default.
• W1924974311 created "2016-06-24" @default.
• W1924974311 creator A5014233875 @default.
• W1924974311 creator A5077375577 @default.
• W1924974311 creator A5078176247 @default.
• W1924974311 date "2014-09-22" @default.
• W1924974311 modified "2023-10-16" @default.
• W1924974311 title "Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity" @default.
• W1924974311 cites W1879098942 @default.
• W1924974311 cites W1887964547 @default.
• W1924974311 cites W1970282834 @default.
• W1924974311 cites W1974068770 @default.
• W1924974311 cites W1980251140 @default.
• W1924974311 cites W1989421367 @default.
• W1924974311 cites W1993547444 @default.
• W1924974311 cites W2022960575 @default.
• W1924974311 cites W2081087321 @default.
• W1924974311 cites W2091705039 @default.
• W1924974311 cites W2098016022 @default.
• W1924974311 cites W2107661394 @default.
• W1924974311 cites W2115436350 @default.
• W1924974311 cites W2115895005 @default.
• W1924974311 cites W2116445432 @default.
• W1924974311 cites W2139155519 @default.
• W1924974311 cites W2148029218 @default.
• W1924974311 cites W2164240864 @default.
• W1924974311 cites W2170523452 @default.
• W1924974311 doi "https://doi.org/10.1002/jat.3071" @default.
• W1924974311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25244189" @default.
• W1924974311 hasPublicationYear "2014" @default.
• W1924974311 type Work @default.
• W1924974311 sameAs 1924974311 @default.
• W1924974311 citedByCount "6" @default.
• W1924974311 countsByYear W19249743112016 @default.
• W1924974311 countsByYear W19249743112017 @default.
• W1924974311 countsByYear W19249743112018 @default.
• W1924974311 countsByYear W19249743112019 @default.
• W1924974311 countsByYear W19249743112021 @default.
• W1924974311 crossrefType "journal-article" @default.
• W1924974311 hasAuthorship W1924974311A5014233875 @default.
• W1924974311 hasAuthorship W1924974311A5077375577 @default.
• W1924974311 hasAuthorship W1924974311A5078176247 @default.
• W1924974311 hasConcept C104317684 @default.
• W1924974311 hasConcept C121587506 @default.
• W1924974311 hasConcept C12174686 @default.
• W1924974311 hasConcept C126322002 @default.
• W1924974311 hasConcept C150194340 @default.
• W1924974311 hasConcept C160798450 @default.
• W1924974311 hasConcept C197934379 @default.
• W1924974311 hasConcept C2780473477 @default.
• W1924974311 hasConcept C2910206359 @default.
• W1924974311 hasConcept C29730261 @default.
• W1924974311 hasConcept C33070731 @default.
• W1924974311 hasConcept C38652104 @default.
• W1924974311 hasConcept C41008148 @default.
• W1924974311 hasConcept C54355233 @default.
• W1924974311 hasConcept C60644358 @default.
• W1924974311 hasConcept C70721500 @default.
• W1924974311 hasConcept C71924100 @default.
• W1924974311 hasConcept C86803240 @default.
• W1924974311 hasConcept C93231420 @default.
• W1924974311 hasConcept C98274493 @default.
• W1924974311 hasConceptScore W1924974311C104317684 @default.
• W1924974311 hasConceptScore W1924974311C121587506 @default.
• W1924974311 hasConceptScore W1924974311C12174686 @default.
• W1924974311 hasConceptScore W1924974311C126322002 @default.
• W1924974311 hasConceptScore W1924974311C150194340 @default.
• W1924974311 hasConceptScore W1924974311C160798450 @default.
• W1924974311 hasConceptScore W1924974311C197934379 @default.
• W1924974311 hasConceptScore W1924974311C2780473477 @default.
• W1924974311 hasConceptScore W1924974311C2910206359 @default.
• W1924974311 hasConceptScore W1924974311C29730261 @default.
• W1924974311 hasConceptScore W1924974311C33070731 @default.
• W1924974311 hasConceptScore W1924974311C38652104 @default.
• W1924974311 hasConceptScore W1924974311C41008148 @default.
• W1924974311 hasConceptScore W1924974311C54355233 @default.
• W1924974311 hasConceptScore W1924974311C60644358 @default.
• W1924974311 hasConceptScore W1924974311C70721500 @default.
• W1924974311 hasConceptScore W1924974311C71924100 @default.
• W1924974311 hasConceptScore W1924974311C86803240 @default.
• W1924974311 hasConceptScore W1924974311C93231420 @default.
• W1924974311 hasConceptScore W1924974311C98274493 @default.
• W1924974311 hasIssue "11" @default.
• W1924974311 hasLocation W19249743111 @default.
• W1924974311 hasLocation W19249743112 @default.
• W1924974311 hasOpenAccess W1924974311 @default.
• W1924974311 hasPrimaryLocation W19249743111 @default.
• W1924974311 hasRelatedWork W2064266303 @default.
• W1924974311 hasRelatedWork W2225006655 @default.
• W1924974311 hasRelatedWork W2297465774 @default.
• W1924974311 hasRelatedWork W2887055972 @default.
• W1924974311 hasRelatedWork W2910367567 @default.
• W1924974311 hasRelatedWork W3088834846 @default.
• W1924974311 hasRelatedWork W3201716817 @default.
• W1924974311 hasRelatedWork W4221113490 @default.
• W1924974311 hasRelatedWork W4285013595 @default.
• W1924974311 hasRelatedWork W4310949124 @default.
• W1924974311 hasVolume "34" @default.

• next