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• W1924996912 abstract "For patients presenting with a ST-segment elevation myocardial infarction (STEMI), early myocardial reperfusion by primary percutaneous coronary intervention (PPCI) remains the most effective treatment strategy for limiting myocardial infarct size, preserving left ventricular systolic function, and preventing the onset of heart failure. Recent advances in PCI technology to improve myocardial reperfusion and the introduction of novel anti-platelet and anti-thrombotic agents to maintain the patency of the infarct-related coronary artery continue to optimize PPCI procedure. However, despite these improvements, STEMI patients still experience significant major adverse cardiovascular events. One major contributing factor has been the inability to protect the heart against the lethal myocardial reperfusion injury, which accompanies PPCI. Past attempts to translate cardioprotective strategies, discovered in experimental studies to prevent lethal myocardial reperfusion injury, into the clinical setting of PPCI have been disappointing. However, a number of recent proof-of-concept clinical studies suggest that the heart can be 'conditioned' to protect itself against lethal myocardial reperfusion injury, as evidenced by a reduction in myocardial infarct size. This can be achieved using either mechanical (such as ischaemic postconditioning, remote ischaemic preconditioning, therapeutic hypothermia, or hyperoxaemia) or pharmacological (such as cyclosporin-A, natriuretic peptide, exenatide) 'conditioning' strategies as adjuncts to PPCI. Furthermore, recent developments in cardiac magnetic resonance (CMR) imaging can provide a non-invasive imaging strategy for assessing the efficacy of these novel adjunctive therapies to PPCI in terms of key surrogate clinical endpoints such as myocardial infarct size, myocardial salvage, left ventricular ejection fraction, and the presence of microvascular obstruction or intramyocardial haemorrhage. In this article, we review the therapeutic potential of 'conditioning' to protect the heart against lethal myocardial reperfusion injury in STEMI patients undergoing PPCI." @default.
• W1924996912 created "2016-06-24" @default.
• W1924996912 creator A5014650682 @default.
• W1924996912 date "2012-04-01" @default.
• W1924996912 modified "2023-09-27" @default.
• W1924996912 title "Conditioning the heart to prevent myocardial reperfusion injury during PPCI" @default.
• W1924996912 cites W1042476336 @default.
• W1924996912 cites W110079119 @default.
• W1924996912 cites W125028120 @default.
• W1924996912 cites W1460672116 @default.
• W1924996912 cites W1497216596 @default.
• W1924996912 cites W1939502209 @default.
• W1924996912 cites W1968315455 @default.
• W1924996912 cites W1973760359 @default.
• W1924996912 cites W1988857681 @default.
• W1924996912 cites W1995855721 @default.
• W1924996912 cites W2006350854 @default.
• W1924996912 cites W2018202915 @default.
• W1924996912 cites W2019889924 @default.
• W1924996912 cites W2019897541 @default.
• W1924996912 cites W2022473516 @default.
• W1924996912 cites W2032715486 @default.
• W1924996912 cites W2033373738 @default.
• W1924996912 cites W2037688699 @default.
• W1924996912 cites W2039070030 @default.
• W1924996912 cites W2040485261 @default.
• W1924996912 cites W2043355876 @default.
• W1924996912 cites W2044467032 @default.
• W1924996912 cites W2047760971 @default.
• W1924996912 cites W2047876380 @default.
• W1924996912 cites W2051298109 @default.
• W1924996912 cites W2056044048 @default.
• W1924996912 cites W2056190116 @default.
• W1924996912 cites W2058128468 @default.
• W1924996912 cites W2060943395 @default.
• W1924996912 cites W2064147834 @default.
• W1924996912 cites W2067185367 @default.
• W1924996912 cites W2071752520 @default.
• W1924996912 cites W2081787098 @default.
• W1924996912 cites W2082527993 @default.
• W1924996912 cites W2085604801 @default.
• W1924996912 cites W2085997287 @default.
• W1924996912 cites W2097094809 @default.
• W1924996912 cites W2097913246 @default.
• W1924996912 cites W2103168295 @default.
• W1924996912 cites W2103924942 @default.
• W1924996912 cites W2105880575 @default.
• W1924996912 cites W2108478561 @default.
• W1924996912 cites W2109614797 @default.
• W1924996912 cites W2114205159 @default.
• W1924996912 cites W2122179672 @default.
• W1924996912 cites W2122359402 @default.
• W1924996912 cites W2122865912 @default.
• W1924996912 cites W2122974654 @default.
• W1924996912 cites W2128960919 @default.
• W1924996912 cites W2130271956 @default.
• W1924996912 cites W2131015734 @default.
• W1924996912 cites W2132679226 @default.
• W1924996912 cites W2133213109 @default.
• W1924996912 cites W2135217811 @default.
• W1924996912 cites W2136009429 @default.
• W1924996912 cites W2136272230 @default.
• W1924996912 cites W2136344623 @default.
• W1924996912 cites W2137445925 @default.
• W1924996912 cites W2140913003 @default.
• W1924996912 cites W2144719598 @default.
• W1924996912 cites W2145048322 @default.
• W1924996912 cites W2146217294 @default.
• W1924996912 cites W2146350062 @default.
• W1924996912 cites W2148233412 @default.
• W1924996912 cites W2150679169 @default.
• W1924996912 cites W2153298328 @default.
• W1924996912 cites W2155638956 @default.
• W1924996912 cites W2156123275 @default.
• W1924996912 cites W2163467127 @default.
• W1924996912 cites W2170098235 @default.
• W1924996912 cites W2170534435 @default.
• W1924996912 cites W2334489933 @default.
• W1924996912 cites W2377980524 @default.
• W1924996912 cites W2547303326 @default.
• W1924996912 cites W2547890628 @default.
• W1924996912 cites W4248685619 @default.
• W1924996912 cites W56976466 @default.
• W1924996912 cites W77831849 @default.
• W1924996912 doi "https://doi.org/10.1177/2048872612438805" @default.
• W1924996912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3760559" @default.
• W1924996912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24062884" @default.
• W1924996912 hasPublicationYear "2012" @default.
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