Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925117719> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1925117719 startingPage "4639" @default.
- W1925117719 abstract "Background: In a recent study has been shown that hMLH1 gene has an additional function in tumorgenesis as a general stimulating factor for miRNA biogenesis. Additionally, a correlation of elevated miR-21 with hMSH2 mRNA levels has been reported in lung cancer cell lines . Aim: To correlate miR-422a, miR-21 and miR-155 levels with hMSH2 and hMLH1, mRNA expression profiles in NSCLCs and their adjacent normal tissues (ANTs).Materials and methods: Quantitation of mature miR-422a, miR-21 and miR-155 was performed in 11 NSCLCs and ANTs, using control-miRNA RNU6. miRNA levels were defined as ratios of target-miRNA/U6 and relative expression as ratios of miRNAs levels in NSCLCs/ANTs. MMR mRNA levels had been established in advance.Results: There was a significant correlation between hMLH1 mRNA levels and miR-422a, miR-21 levels. We also found a significant relationship between cases with elevated hMLH1 and those with elevated miR-21, miR-422a miR-155, compared with cases with low miR-422a, miR-21, miR-155 levels ( p <0.004, p< 0.001, p <0.003, respectively). Cases with elevated miR-422a and miR-21 show more often low hMSH2 levels, than cases with low miR-422a and miR-21 levels ( p <0.004 p< 0.001, respectively). 70% of NSCLCs had reduced miR-422a ratios compare to ANTs. Finally, NSCLCs of stage III expressed higher miR-21 levels ( p <0.05).Conclusions: Our findings 1) support hMLH1 function as a stimulator factor of miRNAs, 2) are in line with miR-422a and miR21 role as regulators of hMSH2 expression, 3) support a tumor-suppressor role of miR-422a and 4) highlight miR-21 marker as an index of tumor progression in lung cancer." @default.
- W1925117719 created "2016-06-24" @default.
- W1925117719 creator A5001990005 @default.
- W1925117719 creator A5031531106 @default.
- W1925117719 creator A5064983758 @default.
- W1925117719 creator A5080033648 @default.
- W1925117719 creator A5088074672 @default.
- W1925117719 creator A5091532223 @default.
- W1925117719 date "2013-09-01" @default.
- W1925117719 modified "2023-09-24" @default.
- W1925117719 title "Correlation of miR-422a, miR-21 and miR-155 analysis with hMSH2 and hMLH1 mRNA expression profiles in non-small cell lung carcinomas and their adjacent normal tissues" @default.
- W1925117719 hasPublicationYear "2013" @default.
- W1925117719 type Work @default.
- W1925117719 sameAs 1925117719 @default.
- W1925117719 citedByCount "1" @default.
- W1925117719 countsByYear W19251177192013 @default.
- W1925117719 crossrefType "journal-article" @default.
- W1925117719 hasAuthorship W1925117719A5001990005 @default.
- W1925117719 hasAuthorship W1925117719A5031531106 @default.
- W1925117719 hasAuthorship W1925117719A5064983758 @default.
- W1925117719 hasAuthorship W1925117719A5080033648 @default.
- W1925117719 hasAuthorship W1925117719A5088074672 @default.
- W1925117719 hasAuthorship W1925117719A5091532223 @default.
- W1925117719 hasConcept C104317684 @default.
- W1925117719 hasConcept C105580179 @default.
- W1925117719 hasConcept C126322002 @default.
- W1925117719 hasConcept C142724271 @default.
- W1925117719 hasConcept C145059251 @default.
- W1925117719 hasConcept C1491633281 @default.
- W1925117719 hasConcept C150194340 @default.
- W1925117719 hasConcept C2777714996 @default.
- W1925117719 hasConcept C502942594 @default.
- W1925117719 hasConcept C54355233 @default.
- W1925117719 hasConcept C71924100 @default.
- W1925117719 hasConcept C86803240 @default.
- W1925117719 hasConceptScore W1925117719C104317684 @default.
- W1925117719 hasConceptScore W1925117719C105580179 @default.
- W1925117719 hasConceptScore W1925117719C126322002 @default.
- W1925117719 hasConceptScore W1925117719C142724271 @default.
- W1925117719 hasConceptScore W1925117719C145059251 @default.
- W1925117719 hasConceptScore W1925117719C1491633281 @default.
- W1925117719 hasConceptScore W1925117719C150194340 @default.
- W1925117719 hasConceptScore W1925117719C2777714996 @default.
- W1925117719 hasConceptScore W1925117719C502942594 @default.
- W1925117719 hasConceptScore W1925117719C54355233 @default.
- W1925117719 hasConceptScore W1925117719C71924100 @default.
- W1925117719 hasConceptScore W1925117719C86803240 @default.
- W1925117719 hasLocation W19251177191 @default.
- W1925117719 hasOpenAccess W1925117719 @default.
- W1925117719 hasPrimaryLocation W19251177191 @default.
- W1925117719 hasRelatedWork W2049665105 @default.
- W1925117719 hasRelatedWork W2061235757 @default.
- W1925117719 hasRelatedWork W2087660989 @default.
- W1925117719 hasRelatedWork W2325128532 @default.
- W1925117719 hasRelatedWork W2341571169 @default.
- W1925117719 hasRelatedWork W2401291858 @default.
- W1925117719 hasRelatedWork W2583294506 @default.
- W1925117719 hasRelatedWork W2598401695 @default.
- W1925117719 hasRelatedWork W2603754250 @default.
- W1925117719 hasRelatedWork W2923792378 @default.
- W1925117719 hasRelatedWork W2969838890 @default.
- W1925117719 hasRelatedWork W2980316773 @default.
- W1925117719 hasRelatedWork W3010016228 @default.
- W1925117719 hasRelatedWork W3032279025 @default.
- W1925117719 hasRelatedWork W3047751293 @default.
- W1925117719 hasRelatedWork W3094531751 @default.
- W1925117719 hasRelatedWork W3122656101 @default.
- W1925117719 hasRelatedWork W3185402785 @default.
- W1925117719 hasRelatedWork W2555727823 @default.
- W1925117719 hasRelatedWork W2601577185 @default.
- W1925117719 hasVolume "42" @default.
- W1925117719 isParatext "false" @default.
- W1925117719 isRetracted "false" @default.
- W1925117719 magId "1925117719" @default.
- W1925117719 workType "article" @default.