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• W1925157258 endingPage "4652" @default.
• W1925157258 startingPage "4643" @default.
• W1925157258 abstract "ABSTRACT Mutagenized human 293 cells containing an interleukin-1 (IL-1)-regulated herpes thymidine kinase gene, selected in IL-1 and gancyclovir, have yielded many independent clones that are unresponsive to IL-1. The four clones analyzed here carry recessive mutations and represent three complementation groups. Mutant A in complementation group I1 lacks IL-1 receptor-associated kinase (IRAK), while the mutants in the other two groups are defective in unknown components that function upstream of IRAK. Expression of exogenous IRAK in I1A cells (I1A-IRAK) restores their responsiveness to IL-1. Neither NFκB nor Jun kinase is activated in IL-1-treated I1A cells, but these responses are restored in I1A-IRAK cells, indicating that IRAK is required for both. To address the role of the kinase activity of IRAK in IL-1 signaling, its ATP binding site was mutated (K239A), completely abolishing kinase activity. In transfected I1A cells, IRAK-K239A was still phosphorylated upon IL-1 stimulation and, surprisingly, still complemented all the defects in the mutant cells. Therefore, IRAK must be phosphorylated by a different kinase, and phospho-IRAK must play a role in IL-1-mediated signaling that does not require its kinase activity." @default.
• W1925157258 created "2016-06-24" @default.
• W1925157258 creator A5019573704 @default.
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• W1925157258 creator A5063231200 @default.
• W1925157258 creator A5072468221 @default.
• W1925157258 creator A5090427988 @default.
• W1925157258 date "1999-07-01" @default.
• W1925157258 modified "2023-09-26" @default.
• W1925157258 title "Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase" @default.
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• W1925157258 doi "https://doi.org/10.1128/mcb.19.7.4643" @default.
• W1925157258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/84262" @default.
• W1925157258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10373513" @default.
• W1925157258 hasPublicationYear "1999" @default.
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