FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925260968> ?p ?o ?g. }

• W1925260968 endingPage "1816" @default.
• W1925260968 startingPage "1809" @default.
• W1925260968 abstract "Abstract Although the role of CD28 in T cell costimulation is firmly established, the mechanisms by which it exerts its costimulatory actions are less clear. In many circumstances it is difficult to distinguish the effects of CD28 from subsequent actions of cytokines, such as IL-2, on T cell proliferation. Here, we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2, as evidenced by both cytokine production and IL-2 promoter stimulation. Promoter assays revealed CD28-dependent effects on both NF-κB and AP-1, but not on NF-AT or the intact IL-2 promoter. In addition, T cell proliferation was completely resistant to the actions of the immunosuppressant cyclosporin A (CsA). Moreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2. We also investigated the effects of stimulating T cell blasts with CD80 alone and found that there was a limited requirement for IL-2 in this system. We conclude that CD28 costimulation can cause substantial T cell proliferation in the absence of IL-2, which is driven by a soluble factor independent of NF-AT transactivation." @default.
• W1925260968 created "2016-06-24" @default.
• W1925260968 creator A5007323928 @default.
• W1925260968 creator A5043119059 @default.
• W1925260968 creator A5070677442 @default.
• W1925260968 creator A5074315158 @default.
• W1925260968 creator A5078001335 @default.
• W1925260968 creator A5089714951 @default.
• W1925260968 date "1999-08-15" @default.
• W1925260968 modified "2023-10-09" @default.
• W1925260968 title "IL-2-Independent Activation and Proliferation in Human T Cells Induced by CD28" @default.
• W1925260968 cites W108215184 @default.
• W1925260968 cites W1488633968 @default.
• W1925260968 cites W1490870966 @default.
• W1925260968 cites W1510071762 @default.
• W1925260968 cites W1511106739 @default.
• W1925260968 cites W1538787080 @default.
• W1925260968 cites W1572004867 @default.
• W1925260968 cites W1631147967 @default.
• W1925260968 cites W1924669997 @default.
• W1925260968 cites W1969772137 @default.
• W1925260968 cites W1980692466 @default.
• W1925260968 cites W1985789743 @default.
• W1925260968 cites W1993210315 @default.
• W1925260968 cites W1994688157 @default.
• W1925260968 cites W2000208875 @default.
• W1925260968 cites W2003243698 @default.
• W1925260968 cites W2004078164 @default.
• W1925260968 cites W2026181894 @default.
• W1925260968 cites W2040572245 @default.
• W1925260968 cites W2041525823 @default.
• W1925260968 cites W2044406741 @default.
• W1925260968 cites W2045877541 @default.
• W1925260968 cites W2054565917 @default.
• W1925260968 cites W2054678965 @default.
• W1925260968 cites W2083984611 @default.
• W1925260968 cites W2090481553 @default.
• W1925260968 cites W2091783976 @default.
• W1925260968 cites W2092109378 @default.
• W1925260968 cites W2095424396 @default.
• W1925260968 cites W2115277104 @default.
• W1925260968 cites W2134372981 @default.
• W1925260968 cites W2139567538 @default.
• W1925260968 cites W2162688081 @default.
• W1925260968 cites W2168931543 @default.
• W1925260968 cites W2172523660 @default.
• W1925260968 cites W2172960056 @default.
• W1925260968 cites W2214620900 @default.
• W1925260968 cites W4243274544 @default.
• W1925260968 doi "https://doi.org/10.4049/jimmunol.163.4.1809" @default.
• W1925260968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10438913" @default.
• W1925260968 hasPublicationYear "1999" @default.
• W1925260968 type Work @default.
• W1925260968 sameAs 1925260968 @default.
• W1925260968 citedByCount "21" @default.
• W1925260968 countsByYear W19252609682012 @default.
• W1925260968 crossrefType "journal-article" @default.
• W1925260968 hasAuthorship W1925260968A5007323928 @default.
• W1925260968 hasAuthorship W1925260968A5043119059 @default.
• W1925260968 hasAuthorship W1925260968A5070677442 @default.
• W1925260968 hasAuthorship W1925260968A5074315158 @default.
• W1925260968 hasAuthorship W1925260968A5078001335 @default.
• W1925260968 hasAuthorship W1925260968A5089714951 @default.
• W1925260968 hasBestOaLocation W19252609681 @default.
• W1925260968 hasConcept C104317684 @default.
• W1925260968 hasConcept C1292079 @default.
• W1925260968 hasConcept C148125776 @default.
• W1925260968 hasConcept C153911025 @default.
• W1925260968 hasConcept C154317977 @default.
• W1925260968 hasConcept C170493617 @default.
• W1925260968 hasConcept C185592680 @default.
• W1925260968 hasConcept C202751555 @default.
• W1925260968 hasConcept C203014093 @default.
• W1925260968 hasConcept C2776090121 @default.
• W1925260968 hasConcept C2778297628 @default.
• W1925260968 hasConcept C2778690821 @default.
• W1925260968 hasConcept C39347974 @default.
• W1925260968 hasConcept C55493867 @default.
• W1925260968 hasConcept C62112901 @default.
• W1925260968 hasConcept C86339819 @default.
• W1925260968 hasConcept C86803240 @default.
• W1925260968 hasConcept C8891405 @default.
• W1925260968 hasConcept C95444343 @default.
• W1925260968 hasConceptScore W1925260968C104317684 @default.
• W1925260968 hasConceptScore W1925260968C1292079 @default.
• W1925260968 hasConceptScore W1925260968C148125776 @default.
• W1925260968 hasConceptScore W1925260968C153911025 @default.
• W1925260968 hasConceptScore W1925260968C154317977 @default.
• W1925260968 hasConceptScore W1925260968C170493617 @default.
• W1925260968 hasConceptScore W1925260968C185592680 @default.
• W1925260968 hasConceptScore W1925260968C202751555 @default.
• W1925260968 hasConceptScore W1925260968C203014093 @default.
• W1925260968 hasConceptScore W1925260968C2776090121 @default.
• W1925260968 hasConceptScore W1925260968C2778297628 @default.
• W1925260968 hasConceptScore W1925260968C2778690821 @default.
• W1925260968 hasConceptScore W1925260968C39347974 @default.
• W1925260968 hasConceptScore W1925260968C55493867 @default.
• W1925260968 hasConceptScore W1925260968C62112901 @default.

• next