FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W192548456> ?p ?o ?g. }

• W192548456 endingPage "L824" @default.
• W192548456 startingPage "L814" @default.
• W192548456 abstract "Increased collagen and extracellular matrix (ECM) deposition within the lung is a characteristic feature of lung fibrosis. Transforming growth factor (TGF)-beta isoforms play a pivotal role in the production of collagen and ECM. In this study, we investigated the effects of TGF-beta1 and TGF-beta3 on the main processes controlling ECM deposition using primary human lung fibroblasts. We analyzed 1) collagen metabolism by [3H]proline incorporation, 2) matrix metalloproteinase (MMP) expression by substrate gel zymography, and 3) tissue inhibitor of metalloproteinases (TIMP) expression by Western blot analysis. TGF-beta1 and TGF-beta3 increased the percentage of secreted collagens in supernatants of primary fibroblasts from 8.0 +/- 1.2 (control) to 23.6 +/- 4.6 and 22.3 +/- 1.3%, respectively. The collagen percentage in deposited ECM was increased from 5.8 +/- 0.3 (control) to 9.0 +/- 0.5 and 8.8 +/- 0.5% by TGF-beta1 and TGF-beta3, respectively. Secretion of MMP-1 (interstitial collagenase) by fibroblasts was reduced by both TGF-beta isoforms, whereas secretion of MMP-2 (gelatinase A) was unaffected by either of the two isoforms. Both TGF-beta isoforms increased TIMP-1 protein expression, whereas TIMP-2 protein was decreased. We thus conclude that TGF-beta1 and TGF-beta3 are equally potent in increasing ECM deposition. Their fibrotic effect in lung fibroblasts results from 1) an increase in the secretion and deposition of total ECM and collagens, 2) a decrease in MMP-1 secretion, and 3) an increase of TIMP-1 expression." @default.
• W192548456 created "2016-06-24" @default.
• W192548456 creator A5009672774 @default.
• W192548456 creator A5012678025 @default.
• W192548456 creator A5026090875 @default.
• W192548456 creator A5034447238 @default.
• W192548456 creator A5070000957 @default.
• W192548456 creator A5073996496 @default.
• W192548456 creator A5077426550 @default.
• W192548456 creator A5078302229 @default.
• W192548456 date "1999-05-01" @default.
• W192548456 modified "2023-10-16" @default.
• W192548456 title "Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3" @default.
• W192548456 cites W1494055834 @default.
• W192548456 cites W1505978562 @default.
• W192548456 cites W1556540426 @default.
• W192548456 cites W1795980252 @default.
• W192548456 cites W1964726028 @default.
• W192548456 cites W1977368722 @default.
• W192548456 cites W1993493586 @default.
• W192548456 cites W2000948507 @default.
• W192548456 cites W2002865693 @default.
• W192548456 cites W2010465872 @default.
• W192548456 cites W2013987164 @default.
• W192548456 cites W2017992936 @default.
• W192548456 cites W2021400005 @default.
• W192548456 cites W2022293686 @default.
• W192548456 cites W2023263965 @default.
• W192548456 cites W2025571426 @default.
• W192548456 cites W2031723327 @default.
• W192548456 cites W2036387557 @default.
• W192548456 cites W2037753264 @default.
• W192548456 cites W2044500153 @default.
• W192548456 cites W2060928333 @default.
• W192548456 cites W2062510144 @default.
• W192548456 cites W2067091655 @default.
• W192548456 cites W2080323238 @default.
• W192548456 cites W2093586592 @default.
• W192548456 cites W2100999067 @default.
• W192548456 cites W2113127336 @default.
• W192548456 cites W2118740066 @default.
• W192548456 cites W2119341928 @default.
• W192548456 cites W2119836992 @default.
• W192548456 cites W2121428870 @default.
• W192548456 cites W2123503971 @default.
• W192548456 cites W2126066210 @default.
• W192548456 cites W2148109597 @default.
• W192548456 cites W2160001887 @default.
• W192548456 cites W2168476587 @default.
• W192548456 cites W2215360874 @default.
• W192548456 cites W2246378037 @default.
• W192548456 cites W2266058855 @default.
• W192548456 cites W2319087989 @default.
• W192548456 cites W2335187016 @default.
• W192548456 cites W4312453736 @default.
• W192548456 doi "https://doi.org/10.1152/ajplung.1999.276.5.l814" @default.
• W192548456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10330038" @default.
• W192548456 hasPublicationYear "1999" @default.
• W192548456 type Work @default.
• W192548456 sameAs 192548456 @default.
• W192548456 citedByCount "133" @default.
• W192548456 countsByYear W1925484562012 @default.
• W192548456 countsByYear W1925484562013 @default.
• W192548456 countsByYear W1925484562014 @default.
• W192548456 countsByYear W1925484562015 @default.
• W192548456 countsByYear W1925484562016 @default.
• W192548456 countsByYear W1925484562017 @default.
• W192548456 countsByYear W1925484562018 @default.
• W192548456 countsByYear W1925484562019 @default.
• W192548456 countsByYear W1925484562020 @default.
• W192548456 countsByYear W1925484562021 @default.
• W192548456 countsByYear W1925484562022 @default.
• W192548456 countsByYear W1925484562023 @default.
• W192548456 crossrefType "journal-article" @default.
• W192548456 hasAuthorship W192548456A5009672774 @default.
• W192548456 hasAuthorship W192548456A5012678025 @default.
• W192548456 hasAuthorship W192548456A5026090875 @default.
• W192548456 hasAuthorship W192548456A5034447238 @default.
• W192548456 hasAuthorship W192548456A5070000957 @default.
• W192548456 hasAuthorship W192548456A5073996496 @default.
• W192548456 hasAuthorship W192548456A5077426550 @default.
• W192548456 hasAuthorship W192548456A5078302229 @default.
• W192548456 hasConcept C104317684 @default.
• W192548456 hasConcept C109523444 @default.
• W192548456 hasConcept C118131993 @default.
• W192548456 hasConcept C126322002 @default.
• W192548456 hasConcept C134018914 @default.
• W192548456 hasConcept C153911025 @default.
• W192548456 hasConcept C177430391 @default.
• W192548456 hasConcept C181199279 @default.
• W192548456 hasConcept C185592680 @default.
• W192548456 hasConcept C189165786 @default.
• W192548456 hasConcept C202751555 @default.
• W192548456 hasConcept C2776232661 @default.
• W192548456 hasConcept C2776415932 @default.
• W192548456 hasConcept C2776747403 @default.
• W192548456 hasConcept C2778229498 @default.
• W192548456 hasConcept C2778394429 @default.

• next