Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925486148> ?p ?o ?g. }
- W1925486148 endingPage "67" @default.
- W1925486148 startingPage "56" @default.
- W1925486148 abstract "There is increasing evidence for non-linear relationships for gene mutations, chromosomal aberrations and even tumor incidences in response to low doses of genotoxic carcinogens. To attain the biological relevance of such non-linear responses, there is a need to identify the underlying defense mechanisms that allow tolerance to low doses of genotoxicants. This communication discusses presumptive cancer prevention mechanisms that may contribute to thresholds, i.e. points of departure, for each endpoint, from initial DNA lesion to tumor formation. We discuss a sequential order of genome protection during carcinogenesis where genotoxicant scavenging, cellular efflux, DNA repair, elimination of damaged cells by apoptosis, autophagy, silencing by DNA damage-triggered replicative senescence, and finally, elimination of transformed (premalignant) cells by the immune system are thought to be responsible for a threshold in tumor formation. We highlight DNA repair, for which experimental evidence has been recently provided to dictate a role in PoDs. In conclusion, from a theoretical perspective it is reasonable to posit that tolerance to low dose levels exists for each requisite step of tumor formation and these tolerance mechanisms are critical in determining thresholds in chemical carcinogenesis." @default.
- W1925486148 created "2016-06-24" @default.
- W1925486148 creator A5020495575 @default.
- W1925486148 creator A5026593378 @default.
- W1925486148 creator A5033128271 @default.
- W1925486148 creator A5084629723 @default.
- W1925486148 date "2015-07-01" @default.
- W1925486148 modified "2023-09-30" @default.
- W1925486148 title "Theoretical considerations for thresholds in chemical carcinogenesis" @default.
- W1925486148 cites W111616551 @default.
- W1925486148 cites W1507283988 @default.
- W1925486148 cites W1512214997 @default.
- W1925486148 cites W1528462551 @default.
- W1925486148 cites W1545398558 @default.
- W1925486148 cites W1845321470 @default.
- W1925486148 cites W1882782347 @default.
- W1925486148 cites W1928688086 @default.
- W1925486148 cites W1963796379 @default.
- W1925486148 cites W1966091763 @default.
- W1925486148 cites W1967090290 @default.
- W1925486148 cites W1969008635 @default.
- W1925486148 cites W1970471893 @default.
- W1925486148 cites W1971344938 @default.
- W1925486148 cites W1972654812 @default.
- W1925486148 cites W1974693247 @default.
- W1925486148 cites W1975145355 @default.
- W1925486148 cites W1975931451 @default.
- W1925486148 cites W1976881265 @default.
- W1925486148 cites W1986450641 @default.
- W1925486148 cites W1986660401 @default.
- W1925486148 cites W1990632598 @default.
- W1925486148 cites W1993209496 @default.
- W1925486148 cites W1993684018 @default.
- W1925486148 cites W1997579443 @default.
- W1925486148 cites W1998023952 @default.
- W1925486148 cites W1998947396 @default.
- W1925486148 cites W1999478182 @default.
- W1925486148 cites W2003559528 @default.
- W1925486148 cites W2004257622 @default.
- W1925486148 cites W2004630197 @default.
- W1925486148 cites W2004745865 @default.
- W1925486148 cites W2006574212 @default.
- W1925486148 cites W2007771316 @default.
- W1925486148 cites W2009882235 @default.
- W1925486148 cites W2012063681 @default.
- W1925486148 cites W2012254133 @default.
- W1925486148 cites W2012732208 @default.
- W1925486148 cites W2012734709 @default.
- W1925486148 cites W2015354385 @default.
- W1925486148 cites W2017838956 @default.
- W1925486148 cites W2018116689 @default.
- W1925486148 cites W2018938581 @default.
- W1925486148 cites W2019514569 @default.
- W1925486148 cites W2019981881 @default.
- W1925486148 cites W2021521537 @default.
- W1925486148 cites W2022736748 @default.
- W1925486148 cites W2029868343 @default.
- W1925486148 cites W2030858260 @default.
- W1925486148 cites W2031576029 @default.
- W1925486148 cites W2031666034 @default.
- W1925486148 cites W2034269086 @default.
- W1925486148 cites W2037621441 @default.
- W1925486148 cites W2037916186 @default.
- W1925486148 cites W2038138598 @default.
- W1925486148 cites W2039077522 @default.
- W1925486148 cites W2039855632 @default.
- W1925486148 cites W2040860750 @default.
- W1925486148 cites W2041156660 @default.
- W1925486148 cites W2041657197 @default.
- W1925486148 cites W2041768024 @default.
- W1925486148 cites W2048556470 @default.
- W1925486148 cites W2049508036 @default.
- W1925486148 cites W2049606715 @default.
- W1925486148 cites W2052508582 @default.
- W1925486148 cites W2052523909 @default.
- W1925486148 cites W2054479186 @default.
- W1925486148 cites W2056772956 @default.
- W1925486148 cites W2059971436 @default.
- W1925486148 cites W2060057454 @default.
- W1925486148 cites W2060813234 @default.
- W1925486148 cites W2061025341 @default.
- W1925486148 cites W2063705036 @default.
- W1925486148 cites W2064488040 @default.
- W1925486148 cites W2066800765 @default.
- W1925486148 cites W2067827196 @default.
- W1925486148 cites W2067984194 @default.
- W1925486148 cites W2068585812 @default.
- W1925486148 cites W2069254986 @default.
- W1925486148 cites W2071457560 @default.
- W1925486148 cites W2075791456 @default.
- W1925486148 cites W2077436902 @default.
- W1925486148 cites W2077858999 @default.
- W1925486148 cites W2078893058 @default.
- W1925486148 cites W2079680569 @default.
- W1925486148 cites W2079828661 @default.
- W1925486148 cites W2082559623 @default.
- W1925486148 cites W2085442981 @default.
- W1925486148 cites W2086333179 @default.