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- W1925508331 abstract "Introduction : Inflammation in asthma involves proximal and distal airways. The latter may induce a significant hyperinflation (HI).Aim: To evaluate the prevalence of HI by body plethysmography in asthmatic patients with poorly controlled disease and/or significant dyspnea.Methods : In 324 patients (age 49 ± 17; FEV1 75 ± 18 % pred) insufficient asthma control was defined by an ACT score < 20 (n = 302) or a significant dyspnea by a MRC score ≥ 1 (n=22).HI was defined by either a RV > pred + 1.64 RSD (=RV-HI) or a FRC > 120 % pred (= FRC-HI). HI reversibility after bronchodilator was defined by a decrease of RV > 20 % or a reduction of FRC > 10 % from baseline. Change in dyspnea and chest tightness were evaluated by a VAS.Results : HI was found in 49 % (RV-HI) and 47 % (FRC-HI) of cases. Prevalence of HI was higher in patients with a FEV1 80 % pred: 78 % for RV-HI and 70 % for FRC-HI, vs 34 % and 40 %, respectively. ACT score was lower in patients with FRC-HI (13.4 ± 4 vs 14.6 ± 4; p = 0.004). Post-bronchodilator change was -10 ± 13 % for FRC, and - 12 ± 21 % for RV. HI reversibility was obtained in 59 % of cases with RV-HI and 47 % of cases with FRC-HI. Chest tightness decrease after bronchodilator was greater in patients with baseline FRC-HI (- 44 ± 25 vs - 37 ± 24 mm, p = 0.02). Dyspnea improvement was higher in those with baseline RV-HI (- 45 ± 26 mm vs - 38 ± 23, p = 0.02).Conclusion : Hyperinflation is frequent in poorly controlled asthma, including patients with normal FEV1, suggesting an involvement of distal airways. It appearsreversible in more than half of cases." @default.
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- W1925508331 date "2012-09-01" @default.
- W1925508331 modified "2023-09-30" @default.
- W1925508331 title "Prevalence of hyperinflation and its reversibility in asthma patients with poorly controlled disease or significant dyspnea" @default.
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