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• W1925510081 startingPage "472" @default.
• W1925510081 abstract "Feeding intolerance (ie, achieving and maintaining full enteral feedings) is a significant problem in preterm infants. A relation exists between feeding intolerance and incomplete lactose digestion.We sought to identify the factors relating to lactose digestion and absorption, lactase activity, and small-intestinal mucosal growth.Lactose digestion and absorption, lactase-specific activity, and lumen-to-mucosa water flux as a measure of small-intestinal mucosal surface area were determined by using the triple-lumen perfusion technique on 2 occasions 3 wk apart in 10 preterm infants (x+/-SEM gestational age: 28.0+/-0.2 wk).Lactose digestion and absorption and lactase activity doubled between studies (P=0.035 and P=0.041, respectively). The change in digestion and absorption was related to lactase activity (P=0.034, R2=0.38). Lactase activity correlated with gestational age at birth (P=0.012, R2=0.51). The number of days of feeding explained 80% of the variability in small-intestinal mucosal surface area (P=0.001).To our knowledge, this is the first study to measure directly lactose digestion and absorption, lactase activity, and small-intestinal surface area in preterm infants. Changes in lactose absorption relate primarily to lactase activity rather than to mucosal growth. We showed directly a relation between enteral feeding and small-intestinal mucosal growth." @default.
• W1925510081 created "2016-06-24" @default.
• W1925510081 creator A5005817077 @default.
• W1925510081 creator A5058844359 @default.
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• W1925510081 date "2005-02-01" @default.
• W1925510081 modified "2023-10-14" @default.
• W1925510081 title "Influence of changes in lactase activity and small-intestinal mucosal growth on lactose digestion and absorption in preterm infants" @default.
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• W1925510081 doi "https://doi.org/10.1093/ajcn.81.2.472" @default.
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