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• W1925649505 startingPage "4695" @default.
• W1925649505 abstract "Efficacy of postsynaptic inhibition through GABA A receptors in the mammalian brain depends on the maintenance of a Cl − gradient for hyperpolarizing Cl − currents. We have taken advantage of the reduced complexity under which Cl − regulation can be investigated in cultured neurons as opposed to neurons in other in vitro preparations of the mammalian brain. Tightseal whole-cell recording of spontaneous GABA A receptor-mediated postsynaptic currents suggested that an outward Cl − transport reduced dendritic [Cl − ] i if the somata of cells were loaded with Cl − via the patch pipette. We determined dendritic and somatic reversal potentials of Cl − currents induced by focally applied GABA to calculate [Cl − ] i during variation of [K + ] o and [Cl − ] in the patch pipette. [Cl − ] i and [K + ] o were tightly coupled by a furosemide-sensitive K + –Cl − cotransport. Thermodynamic considerations excluded the significant contribution of a Na + –K + –Cl − cotransporter to the net Cl − transport. We conclude that under conditions of normal [K + ] o the K + –Cl − cotransporter helps to maintain [Cl − ] i at low levels, whereas under pathological conditions, under which [K + ] o remains elevated because of neuronal hyperactivity, the cotransporter accumulates Cl − in neurons, thereby further enhancing neuronal excitability." @default.
• W1925649505 created "2016-06-24" @default.
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• W1925649505 creator A5054358556 @default.
• W1925649505 creator A5069460049 @default.
• W1925649505 date "1999-06-15" @default.
• W1925649505 modified "2023-09-25" @default.
• W1925649505 title "A Furosemide-Sensitive K⁺–Cl⁻Cotransporter Counteracts Intracellular Cl⁻Accumulation and Depletion in Cultured Rat Midbrain Neurons" @default.
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• W1925649505 doi "https://doi.org/10.1523/jneurosci.19-12-04695.1999" @default.
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