Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925682362> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1925682362 abstract "Peter van Galen focuses on understanding the determinants that maintain the stem cell state. Using human hematopoietic stem cells (HSCs) as a model, processes that govern self-renewal and tissue regeneration were investigated. Specifically, a role for microRNAs in balancing the human HSC quiescence/proliferation equilibrium was uncovered. By attenuating PI3K/AKT signaling, miR-126 restrains HSC proliferation. Second, it was shown that ID proteins restrain expression of differentiation-associated genes in HSCs (lineage priming), thereby enhancing self-renewal of HSCs. Exploiting the link between lineage priming and the stem cell state can be used to successfully expand human HSCs in vivo. As well, a new role for stress signaling in the maintenance of HSC pool integrity was uncovered. Through differential activation of the Unfolded Protein Response pathway in HSCs compared to progenitors, damaged HSCs are purged from the blood system. This process is thought to limit damage accumulation in the stem cell pool and enable tissue regeneration throughout life. Overall, mechanisms are uncovered that balance human HSC quiescence/proliferation, self-renewal/differentiation and apoptosis/survival." @default.
- W1925682362 created "2016-06-24" @default.
- W1925682362 creator A5007638672 @default.
- W1925682362 date "2014-01-01" @default.
- W1925682362 modified "2023-09-27" @default.
- W1925682362 title "Molecular regulation of human hematopoietic stem cells" @default.
- W1925682362 hasPublicationYear "2014" @default.
- W1925682362 type Work @default.
- W1925682362 sameAs 1925682362 @default.
- W1925682362 citedByCount "0" @default.
- W1925682362 crossrefType "journal-article" @default.
- W1925682362 hasAuthorship W1925682362A5007638672 @default.
- W1925682362 hasConcept C100701293 @default.
- W1925682362 hasConcept C104317684 @default.
- W1925682362 hasConcept C109159458 @default.
- W1925682362 hasConcept C14218858 @default.
- W1925682362 hasConcept C148738053 @default.
- W1925682362 hasConcept C171056886 @default.
- W1925682362 hasConcept C201750760 @default.
- W1925682362 hasConcept C2022786 @default.
- W1925682362 hasConcept C203014093 @default.
- W1925682362 hasConcept C20875687 @default.
- W1925682362 hasConcept C2778086970 @default.
- W1925682362 hasConcept C28328180 @default.
- W1925682362 hasConcept C54355233 @default.
- W1925682362 hasConcept C59822182 @default.
- W1925682362 hasConcept C62478195 @default.
- W1925682362 hasConcept C81444415 @default.
- W1925682362 hasConcept C86554907 @default.
- W1925682362 hasConcept C86803240 @default.
- W1925682362 hasConcept C95444343 @default.
- W1925682362 hasConceptScore W1925682362C100701293 @default.
- W1925682362 hasConceptScore W1925682362C104317684 @default.
- W1925682362 hasConceptScore W1925682362C109159458 @default.
- W1925682362 hasConceptScore W1925682362C14218858 @default.
- W1925682362 hasConceptScore W1925682362C148738053 @default.
- W1925682362 hasConceptScore W1925682362C171056886 @default.
- W1925682362 hasConceptScore W1925682362C201750760 @default.
- W1925682362 hasConceptScore W1925682362C2022786 @default.
- W1925682362 hasConceptScore W1925682362C203014093 @default.
- W1925682362 hasConceptScore W1925682362C20875687 @default.
- W1925682362 hasConceptScore W1925682362C2778086970 @default.
- W1925682362 hasConceptScore W1925682362C28328180 @default.
- W1925682362 hasConceptScore W1925682362C54355233 @default.
- W1925682362 hasConceptScore W1925682362C59822182 @default.
- W1925682362 hasConceptScore W1925682362C62478195 @default.
- W1925682362 hasConceptScore W1925682362C81444415 @default.
- W1925682362 hasConceptScore W1925682362C86554907 @default.
- W1925682362 hasConceptScore W1925682362C86803240 @default.
- W1925682362 hasConceptScore W1925682362C95444343 @default.
- W1925682362 hasLocation W19256823621 @default.
- W1925682362 hasOpenAccess W1925682362 @default.
- W1925682362 hasPrimaryLocation W19256823621 @default.
- W1925682362 hasRelatedWork W1785287580 @default.
- W1925682362 hasRelatedWork W1985846572 @default.
- W1925682362 hasRelatedWork W1987990940 @default.
- W1925682362 hasRelatedWork W2028060338 @default.
- W1925682362 hasRelatedWork W2088603400 @default.
- W1925682362 hasRelatedWork W2099977590 @default.
- W1925682362 hasRelatedWork W2121709505 @default.
- W1925682362 hasRelatedWork W2125305878 @default.
- W1925682362 hasRelatedWork W2165225182 @default.
- W1925682362 hasRelatedWork W2296198062 @default.
- W1925682362 hasRelatedWork W2323929941 @default.
- W1925682362 hasRelatedWork W2511844566 @default.
- W1925682362 hasRelatedWork W2612495784 @default.
- W1925682362 hasRelatedWork W2804888680 @default.
- W1925682362 hasRelatedWork W3129561946 @default.
- W1925682362 hasRelatedWork W3182217228 @default.
- W1925682362 hasRelatedWork W3208165694 @default.
- W1925682362 hasRelatedWork W488204 @default.
- W1925682362 hasRelatedWork W1889600192 @default.
- W1925682362 hasRelatedWork W2737741025 @default.
- W1925682362 isParatext "false" @default.
- W1925682362 isRetracted "false" @default.
- W1925682362 magId "1925682362" @default.
- W1925682362 workType "article" @default.