FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925741490> ?p ?o ?g. }

• W1925741490 endingPage "63" @default.
• W1925741490 startingPage "954" @default.
• W1925741490 abstract "The objective of this study was to determine whether the voltage-sensitive release mechanism (VSRM) can be stimulated independently from Ca(2+)-induced Ca(2+) release (CICR) by drugs that elevate intracellular cAMP. Contractions were measured in voltage-clamped guinea pig ventricular myocytes at 37 degrees C. Na(+) current was blocked. We compared effects of agents that elevate cAMP through activation of adenylyl cyclase (1 microM forskolin), nonspecific inhibition of phosphodiesterases (PDEs) [100 microM 3-isobutyl-1-methylxanthine (IBMX)], and selective inhibition of PDE III (100-500 microM amrinone) on contractions initiated by the VSRM and CICR. Forskolin and IBMX significantly increased peak Ca(2+) current and CICR. In addition, these agents also markedly increased contractions elicited by test steps from -65 to -40 mV, which activate the VSRM. However, because these steps also induced inward current in the presence of forskolin or IBMX, CICR could not be excluded. In contrast, amrinone caused a large, concentration-dependent increase in VSRM contractions but had no effect on CICR contractions or Ca(2+) current. Sarcoplasmic reticulum Ca(2+), assessed by rapid application of caffeine (10 mM), was increased only modestly by all three drugs. Normalization of contractions to caffeine contractures indicated that amrinone increased fractional release by the VSRM, but not CICR. Forskolin and IBMX increased fractional release elicited by steps to -40 mV. Increases in CICR induced by forskolin and IBMX were proportional to caffeine contractures. Thus, positive inotropic effects of cAMP on VSRM contractions may be compartmentalized separately from effects on Ca(2+) current and CICR." @default.
• W1925741490 created "2016-06-24" @default.
• W1925741490 creator A5019055538 @default.
• W1925741490 creator A5036408326 @default.
• W1925741490 creator A5044537891 @default.
• W1925741490 creator A5069667750 @default.
• W1925741490 date "2001-09-01" @default.
• W1925741490 modified "2023-10-17" @default.
• W1925741490 title "In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release." @default.
• W1925741490 cites W1511168112 @default.
• W1925741490 cites W152949758 @default.
• W1925741490 cites W1572747936 @default.
• W1925741490 cites W1585924413 @default.
• W1925741490 cites W1593151186 @default.
• W1925741490 cites W1604404976 @default.
• W1925741490 cites W1851168822 @default.
• W1925741490 cites W1899877571 @default.
• W1925741490 cites W1971033431 @default.
• W1925741490 cites W1978867040 @default.
• W1925741490 cites W1986874340 @default.
• W1925741490 cites W1997068815 @default.
• W1925741490 cites W2009291798 @default.
• W1925741490 cites W2024881120 @default.
• W1925741490 cites W2055984902 @default.
• W1925741490 cites W2056445422 @default.
• W1925741490 cites W2060404311 @default.
• W1925741490 cites W2061902990 @default.
• W1925741490 cites W2070173566 @default.
• W1925741490 cites W2089352351 @default.
• W1925741490 cites W2095855647 @default.
• W1925741490 cites W2130999178 @default.
• W1925741490 cites W2134045468 @default.
• W1925741490 cites W2140313980 @default.
• W1925741490 cites W2150724213 @default.
• W1925741490 cites W2153276700 @default.
• W1925741490 cites W2170164022 @default.
• W1925741490 cites W2172519975 @default.
• W1925741490 cites W2221662852 @default.
• W1925741490 cites W2226034083 @default.
• W1925741490 cites W2226437153 @default.
• W1925741490 cites W2231418245 @default.
• W1925741490 cites W2266841333 @default.
• W1925741490 cites W2311681833 @default.
• W1925741490 cites W2403195379 @default.
• W1925741490 cites W2409242026 @default.
• W1925741490 cites W2417794313 @default.
• W1925741490 cites W2483989415 @default.
• W1925741490 cites W47202467 @default.
• W1925741490 cites W96550900 @default.
• W1925741490 cites W986009775 @default.
• W1925741490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11504790" @default.
• W1925741490 hasPublicationYear "2001" @default.
• W1925741490 type Work @default.
• W1925741490 sameAs 1925741490 @default.
• W1925741490 citedByCount "1" @default.
• W1925741490 crossrefType "journal-article" @default.
• W1925741490 hasAuthorship W1925741490A5019055538 @default.
• W1925741490 hasAuthorship W1925741490A5036408326 @default.
• W1925741490 hasAuthorship W1925741490A5044537891 @default.
• W1925741490 hasAuthorship W1925741490A5069667750 @default.
• W1925741490 hasConcept C126322002 @default.
• W1925741490 hasConcept C134018914 @default.
• W1925741490 hasConcept C155710745 @default.
• W1925741490 hasConcept C181199279 @default.
• W1925741490 hasConcept C185592680 @default.
• W1925741490 hasConcept C24998067 @default.
• W1925741490 hasConcept C2776766087 @default.
• W1925741490 hasConcept C2778500429 @default.
• W1925741490 hasConcept C2779276759 @default.
• W1925741490 hasConcept C2779739782 @default.
• W1925741490 hasConcept C2781298581 @default.
• W1925741490 hasConcept C519063684 @default.
• W1925741490 hasConcept C55493867 @default.
• W1925741490 hasConcept C62826618 @default.
• W1925741490 hasConcept C71924100 @default.
• W1925741490 hasConcept C86803240 @default.
• W1925741490 hasConceptScore W1925741490C126322002 @default.
• W1925741490 hasConceptScore W1925741490C134018914 @default.
• W1925741490 hasConceptScore W1925741490C155710745 @default.
• W1925741490 hasConceptScore W1925741490C181199279 @default.
• W1925741490 hasConceptScore W1925741490C185592680 @default.
• W1925741490 hasConceptScore W1925741490C24998067 @default.
• W1925741490 hasConceptScore W1925741490C2776766087 @default.
• W1925741490 hasConceptScore W1925741490C2778500429 @default.
• W1925741490 hasConceptScore W1925741490C2779276759 @default.
• W1925741490 hasConceptScore W1925741490C2779739782 @default.
• W1925741490 hasConceptScore W1925741490C2781298581 @default.
• W1925741490 hasConceptScore W1925741490C519063684 @default.
• W1925741490 hasConceptScore W1925741490C55493867 @default.
• W1925741490 hasConceptScore W1925741490C62826618 @default.
• W1925741490 hasConceptScore W1925741490C71924100 @default.
• W1925741490 hasConceptScore W1925741490C86803240 @default.
• W1925741490 hasIssue "3" @default.
• W1925741490 hasLocation W19257414901 @default.
• W1925741490 hasOpenAccess W1925741490 @default.
• W1925741490 hasPrimaryLocation W19257414901 @default.
• W1925741490 hasRelatedWork W1925741490 @default.
• W1925741490 hasRelatedWork W1981626358 @default.

• next