Matches in SemOpenAlex for { <https://semopenalex.org/work/W19259582> ?p ?o ?g. }
- W19259582 endingPage "1056" @default.
- W19259582 startingPage "1037" @default.
- W19259582 abstract "The endoplasmic reticulum stress response (ESR) is essential for maintaining cellular homeostasis in response to noxious internal and external stimuli. In malignant gliomas, ESR is induced by a low nutrient, hypoxic microenvironment, compounded by external chemotherapy and radiation therapy. Powerful protective mechanisms, including induction of the ER chaperone glucose-regulated protein 78 (GRP78), protect the glioma cells from undergoing apoptosis. This chapter reviews the ESR and how it may be modulated to induce apoptosis in malignant gliomas. Downregulation of protective mechanisms such as GRP78 may be obtained with drugs such as the green tea extract epigallocatechin gallate (EGCG), leading to increased apoptosis when glioma cells are treated with the chemotherapeutic agent temozolomide (TMZ). Conversely, glioma apoptosis may also be induced by increasing ER stress to overwhelming levels with inhibitors of sarcoplasmic/ER calcium ATPase (SERCA) such as celecoxib and dimethyl-celecoxib. Protease inhibitors such as nelfinavir also inhibit proteasome activity, leading to accumulation of misfolded proteins, triggering ER stress. These modulations of the ESR may thus lead to chemotherapy or radiation sensitization of malignant gliomas. Further understanding of the ESR in glioma cells may lead to new treatments for this currently incurable cancer." @default.
- W19259582 created "2016-06-24" @default.
- W19259582 creator A5003363712 @default.
- W19259582 creator A5032045457 @default.
- W19259582 creator A5040401155 @default.
- W19259582 date "2009-01-01" @default.
- W19259582 modified "2023-09-25" @default.
- W19259582 title "Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy" @default.
- W19259582 cites W1593721960 @default.
- W19259582 cites W1854271270 @default.
- W19259582 cites W1965024427 @default.
- W19259582 cites W1965541995 @default.
- W19259582 cites W1970202484 @default.
- W19259582 cites W1979955384 @default.
- W19259582 cites W1986577961 @default.
- W19259582 cites W1995786747 @default.
- W19259582 cites W1996406984 @default.
- W19259582 cites W1997500225 @default.
- W19259582 cites W1998626286 @default.
- W19259582 cites W1998876742 @default.
- W19259582 cites W2007078899 @default.
- W19259582 cites W2008497004 @default.
- W19259582 cites W2013852713 @default.
- W19259582 cites W2017247516 @default.
- W19259582 cites W2019927904 @default.
- W19259582 cites W2025511820 @default.
- W19259582 cites W2027727753 @default.
- W19259582 cites W2028389069 @default.
- W19259582 cites W2031376430 @default.
- W19259582 cites W2033498682 @default.
- W19259582 cites W2034539919 @default.
- W19259582 cites W2039810057 @default.
- W19259582 cites W2048456744 @default.
- W19259582 cites W2054160636 @default.
- W19259582 cites W2054451338 @default.
- W19259582 cites W2060045688 @default.
- W19259582 cites W2072185042 @default.
- W19259582 cites W2076496758 @default.
- W19259582 cites W2077268483 @default.
- W19259582 cites W2077546705 @default.
- W19259582 cites W2079796760 @default.
- W19259582 cites W2080071021 @default.
- W19259582 cites W2086973335 @default.
- W19259582 cites W2087904586 @default.
- W19259582 cites W2096287682 @default.
- W19259582 cites W2104672339 @default.
- W19259582 cites W2107601804 @default.
- W19259582 cites W2110524342 @default.
- W19259582 cites W2113915760 @default.
- W19259582 cites W2120080326 @default.
- W19259582 cites W2120731325 @default.
- W19259582 cites W2127034714 @default.
- W19259582 cites W2127820455 @default.
- W19259582 cites W2136679918 @default.
- W19259582 cites W2144440669 @default.
- W19259582 cites W2144566814 @default.
- W19259582 cites W2148172443 @default.
- W19259582 cites W2151151062 @default.
- W19259582 cites W2152398979 @default.
- W19259582 cites W2157270051 @default.
- W19259582 cites W2167454223 @default.
- W19259582 cites W2168987973 @default.
- W19259582 cites W2240745411 @default.
- W19259582 cites W2254386269 @default.
- W19259582 cites W4255760236 @default.
- W19259582 doi "https://doi.org/10.1007/978-1-60327-553-8_43" @default.
- W19259582 hasPublicationYear "2009" @default.
- W19259582 type Work @default.
- W19259582 sameAs 19259582 @default.
- W19259582 citedByCount "0" @default.
- W19259582 crossrefType "book-chapter" @default.
- W19259582 hasAuthorship W19259582A5003363712 @default.
- W19259582 hasAuthorship W19259582A5032045457 @default.
- W19259582 hasAuthorship W19259582A5040401155 @default.
- W19259582 hasConcept C104317684 @default.
- W19259582 hasConcept C127561419 @default.
- W19259582 hasConcept C139447449 @default.
- W19259582 hasConcept C158617107 @default.
- W19259582 hasConcept C181199279 @default.
- W19259582 hasConcept C185592680 @default.
- W19259582 hasConcept C190283241 @default.
- W19259582 hasConcept C23265538 @default.
- W19259582 hasConcept C2777389519 @default.
- W19259582 hasConcept C2778227246 @default.
- W19259582 hasConcept C2781414619 @default.
- W19259582 hasConcept C502942594 @default.
- W19259582 hasConcept C55493867 @default.
- W19259582 hasConcept C71924100 @default.
- W19259582 hasConcept C98274493 @default.
- W19259582 hasConceptScore W19259582C104317684 @default.
- W19259582 hasConceptScore W19259582C127561419 @default.
- W19259582 hasConceptScore W19259582C139447449 @default.
- W19259582 hasConceptScore W19259582C158617107 @default.
- W19259582 hasConceptScore W19259582C181199279 @default.
- W19259582 hasConceptScore W19259582C185592680 @default.
- W19259582 hasConceptScore W19259582C190283241 @default.
- W19259582 hasConceptScore W19259582C23265538 @default.
- W19259582 hasConceptScore W19259582C2777389519 @default.