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- W1925973653 abstract "Abstract Many cancers and benign tumours probably result, at least in part, from inherited factors. In addition, the presenting features of cancers, response to treatment, and outcome may depend on genetic influences. For most patients, these genetic factors are likely to take the form of alleles with small effects on risk or tumour behaviour, and most of the genes involved have not yet been characterized. The Mendelian (single gene) predisposition disorders that are associated with a high lifetime risk of cancer and/or benign tumours have been better characterized. Although there is considerable heterogeneity in these conditions in terms of the genes involved, tumour site, multiplicity of tumours, molecular pathways involved, and underlying mechanisms of tumourigenesis, most Mendelian tumour susceptibility genes are dominantly inherited tumour suppressors that normally restrain cell proliferation in some way, or recessively inherited alleles involved in DNA repair or the maintenance of genome integrity. Many of the genes involved in the Mendelian syndromes are mutated or otherwise altered somatically in sporadic cancers. Genetic testing for the Mendelian conditions is now largely routine, but should large numbers of low‐risk alleles be identified, the potential financial burden of population‐level genetic testing will be great. It will, therefore, be important to make sure that this testing is used selectively for cancers for which prevention is possible and is most effectively targeted at those with increased genetic risk." @default.
- W1925973653 created "2016-06-24" @default.
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- W1925973653 date "2007-10-15" @default.
- W1925973653 modified "2023-10-10" @default.
- W1925973653 title "Genetic Susceptibility to Cancer" @default.
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- W1925973653 doi "https://doi.org/10.1002/9780470025079.chap04.pub2" @default.
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