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• W1926044927 endingPage "1808" @default.
• W1926044927 startingPage "1793" @default.
• W1926044927 abstract "Spinal muscular atrophy (SMA) is a major neurodegenerative disorder of children and infants. SMA is primarily caused by low levels of SMN protein owing to deletions or mutations of the SMN1 gene. SMN2, a nearly identical copy of SMN1, fails to compensate for the loss of the production of the functional SMN protein due to predominant skipping of exon 7. Several compounds, including antisense oligonucleotides (ASOs) that elevate SMN protein from SMN2 hold the promise for treatment. An ASO-based drug currently under Phase III clinical trial employs intronic splicing silencer N1 (ISS-N1) as its target. Cumulative studies on ISS-N1 reveal a wealth of information with significance to the overall therapeutic development for SMA. Here, the authors summarize the mechanistic principles behind various antisense targets currently available for SMA therapy." @default.
• W1926044927 created "2016-06-24" @default.
• W1926044927 creator A5003781254 @default.
• W1926044927 creator A5004611185 @default.
• W1926044927 creator A5049171215 @default.
• W1926044927 creator A5061593500 @default.
• W1926044927 date "2015-09-01" @default.
• W1926044927 modified "2023-10-01" @default.
• W1926044927 title "Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy" @default.
• W1926044927 cites W14498347 @default.
• W1926044927 cites W1572635945 @default.
• W1926044927 cites W1580690721 @default.
• W1926044927 cites W1879343101 @default.
• W1926044927 cites W1963580438 @default.
• W1926044927 cites W1964668113 @default.
• W1926044927 cites W1965173343 @default.
• W1926044927 cites W1968479063 @default.
• W1926044927 cites W1974226216 @default.
• W1926044927 cites W1977592362 @default.
• W1926044927 cites W1977595548 @default.
• W1926044927 cites W1979404984 @default.
• W1926044927 cites W1979816193 @default.
• W1926044927 cites W1980477780 @default.
• W1926044927 cites W1980922145 @default.
• W1926044927 cites W1985230324 @default.
• W1926044927 cites W1986164507 @default.
• W1926044927 cites W1987441541 @default.
• W1926044927 cites W1988037421 @default.
• W1926044927 cites W1988447677 @default.
• W1926044927 cites W1992500475 @default.
• W1926044927 cites W1992985034 @default.
• W1926044927 cites W1996417439 @default.
• W1926044927 cites W1997761582 @default.
• W1926044927 cites W1997908444 @default.
• W1926044927 cites W2000725203 @default.
• W1926044927 cites W2006167464 @default.
• W1926044927 cites W2010153175 @default.
• W1926044927 cites W2011474181 @default.
• W1926044927 cites W2015026135 @default.
• W1926044927 cites W2016207006 @default.
• W1926044927 cites W2016374051 @default.
• W1926044927 cites W2024685343 @default.
• W1926044927 cites W2024934554 @default.
• W1926044927 cites W2025722577 @default.
• W1926044927 cites W2025816722 @default.
• W1926044927 cites W2026210277 @default.
• W1926044927 cites W2028920559 @default.
• W1926044927 cites W2031700674 @default.
• W1926044927 cites W2031889777 @default.
• W1926044927 cites W2034960937 @default.
• W1926044927 cites W2037367916 @default.
• W1926044927 cites W2040780606 @default.
• W1926044927 cites W2041811354 @default.
• W1926044927 cites W2046387002 @default.
• W1926044927 cites W2049273201 @default.
• W1926044927 cites W2052064222 @default.
• W1926044927 cites W2052064543 @default.
• W1926044927 cites W2054380003 @default.
• W1926044927 cites W2055583355 @default.
• W1926044927 cites W2058745674 @default.
• W1926044927 cites W2059754026 @default.
• W1926044927 cites W2060940070 @default.
• W1926044927 cites W2062238769 @default.
• W1926044927 cites W2062978326 @default.
• W1926044927 cites W2068076855 @default.
• W1926044927 cites W2071086380 @default.
• W1926044927 cites W2073293358 @default.
• W1926044927 cites W2077548086 @default.
• W1926044927 cites W2078578510 @default.
• W1926044927 cites W2080464008 @default.
• W1926044927 cites W2082236797 @default.
• W1926044927 cites W2085465310 @default.
• W1926044927 cites W2088151363 @default.
• W1926044927 cites W2088338354 @default.
• W1926044927 cites W2091907886 @default.
• W1926044927 cites W2094108169 @default.
• W1926044927 cites W2097742989 @default.
• W1926044927 cites W2097956925 @default.
• W1926044927 cites W2101970831 @default.
• W1926044927 cites W2102794547 @default.
• W1926044927 cites W2105010877 @default.
• W1926044927 cites W2107257806 @default.
• W1926044927 cites W2108430210 @default.
• W1926044927 cites W2108665093 @default.
• W1926044927 cites W2109273258 @default.
• W1926044927 cites W2111779228 @default.
• W1926044927 cites W2112430789 @default.
• W1926044927 cites W2112926594 @default.
• W1926044927 cites W2114936022 @default.
• W1926044927 cites W2119330162 @default.
• W1926044927 cites W2119343790 @default.
• W1926044927 cites W2122183801 @default.
• W1926044927 cites W2132110012 @default.
• W1926044927 cites W2136868631 @default.
• W1926044927 cites W2137516955 @default.
• W1926044927 cites W2138377745 @default.
• W1926044927 cites W2141458509 @default.
• W1926044927 cites W2142120640 @default.

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