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- W192616243 endingPage "412" @default.
- W192616243 startingPage "390" @default.
- W192616243 abstract "Exposure of tumor cells to ionizing radiation (IR) is widely known to induce a number of cellular changes. One way that IR can affect tumor cells is through the development of neoantigens which are new molecules that tumor cells express at the cell membrane following some insult or change to the cell. There have been numerous reports in the literature of changes in both tumor and tumor vasculature cell surface molecule expression following treatment with IR. The usefulness of neoantigens for imaging and therapeutic applications lies in the fact that they are differentially expressed on the surface of irradiated tumor cells to a greater extent than on normal tissues. This differential expression provides a mechanism by which tumor cells can be marked by radiation for further targeting. Drug delivery vehicles or imaging agents conjugated to ligands that recognize and interact with the neoantigens can help to improve tumor-specific targeting and reduce systemic toxicity with cancer drugs. This article provides a review of the molecules that have been reported to be expressed on the surface of tumor cells in response to IR either in vivo or in vitro. Additionally, we provide a discussion of some of the methods used in the identification of these antigens and applications for their use in drug delivery and imaging." @default.
- W192616243 created "2016-06-24" @default.
- W192616243 creator A5006343520 @default.
- W192616243 creator A5010741371 @default.
- W192616243 creator A5022827643 @default.
- W192616243 date "2011-01-25" @default.
- W192616243 modified "2023-09-25" @default.
- W192616243 title "Radiation-induced tumor neoantigens: imaging and therapeutic implications." @default.
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