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• W192620984 abstract "This chapter describes methods for perfusing different structures of the brain. Among the problems concerning the function of the living brain is a most difficult question pertaining to the neurochemical events involved in mediating a given pattern of behavior. Each experimental finding contributes in a small way to a clearer understanding of the vital cerebral systems underlying the basic mechanisms that exert a control over individual behavioral and physiological systems. The methods of ventricular perfusion can be employed to investigate the regional release of a substance or the selective action of a drug on an area within the ventricular cavity. That means the anterior horn, inferior horn, or even the dorsal or ventral half of the third ventricle can be perfused individually. Further, the region surrounding the cisterna magna may be excluded entirely from the path of the perfusion medium. The applications of the push–pull perfusion method have also been extended to the cross-perfusion, sometimes called transfusion of effluents, between individual structures in the brains of two conscious animals. Effluent collected from one site in the brain-stem of a donor, which is exposed to a physiological stimulus or change of some sort, is transfused to a homologous site in a recipient animal, and the behavioral and physiological changes in the second animal are recorded. Among the functions examined so far using this direct assay method are the diencephalic and mesencephalic humoral mechanisms involved in the regulation of body temperature, hunger and thirst, and sleep." @default.
• W192620984 created "2016-06-24" @default.
• W192620984 creator A5029172289 @default.
• W192620984 date "1972-01-01" @default.
• W192620984 modified "2023-10-10" @default.
• W192620984 title "Methods for Perfusing Different Structures of the Brain" @default.
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• W192620984 doi "https://doi.org/10.1016/b978-0-12-512302-0.50011-0" @default.
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