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- W1926375223 endingPage "577" @default.
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- W1926375223 abstract "High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA. © 2014 IUBMB Life, 66(8):572–577, 2014" @default.
- W1926375223 created "2016-06-24" @default.
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- W1926375223 date "2014-07-14" @default.
- W1926375223 modified "2023-10-02" @default.
- W1926375223 title "Penicillin-binding protein 2a of methicillin-resistant<i>Staphylococcus aureus</i>" @default.
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- W1926375223 doi "https://doi.org/10.1002/iub.1289" @default.
- W1926375223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4236225" @default.
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