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• W1926486688 abstract "Rats fed a diet with high fat concentration produce larger amounts of milk with a higher lipid concentration than rats fed a lower fat diet. This investigation was designed to study the relationship between dietary fat intake, mammary gland lipid uptake and lipogenesis in rat dams fed, during pregnancy and lactation, one of two purified diets, with equal energy density, containing 2.5 (LL) or 20 g fat/100 g diet (HL). Milk lipid concentration and fatty acid composition were determined at d 14 of lactation. Mammary gland lipogenesis, lipoprotein lipase (LPL) activity and the uptake of [1-14C]triolein by the mammary gland and its transfer to the pups was measured. The intestinal absorption of oral 14C-lipid, 14CO2 production and the amount of 14C-lipid transferred to the pups (milk clot + pups carcass) were significantly higher in the HL group than in the LL group (P < 0.05). Mammary gland lipogenesis was 75% lower and LPL activity was 30% higher in the HL group (P < 0.05). Medium-chain fatty acids (C6–C14) excretion was 46% lower and that of long-chain fatty acids was 142% (P < 0.001) higher in the HL group than in the LL group. The higher milk lipid excretion in the rats fed a high-fat diet resulted from a larger uptake of dietary lipid by the mammary gland, indicated by a larger transfer of 14C-lipid to the pups and by a higher LPL activity in the mammary gland." @default.
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• W1926486688 date "1999-08-01" @default.
• W1926486688 modified "2023-09-30" @default.
• W1926486688 title "A High Dietary Lipid Intake during Pregnancy and Lactation Enhances Mammary Gland Lipid Uptake and Lipoprotein Lipase Activity in Rats" @default.
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• W1926486688 doi "https://doi.org/10.1093/jn/129.8.1574" @default.
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