Matches in SemOpenAlex for { <https://semopenalex.org/work/W1926553611> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1926553611 abstract "Glutamate is the major excitatory neurotransmitter in the brain. Its removal occurs via excitatory amino acid transporters (EAATs) located on glia (EAAT1 & 2) and neurons (EAAT3 & 4). This removal is important in normal synaptic functioning as well as in pathological conditions. The goal of this study was to determine the molecular and functional changes in glial EAATs in the nTS due to sustained hypoxia (SH). Male Sprague-Dawley rats (4-7 weeks) were exposed to 1 or 3 days of SH (10% O2) and compared to normoxic (N) controls. The nTS was harvested for quantitative real-time PCR, immunohistochemistry and immunoblots to evaluate expression of EAAT1 & 2. To examine EAAT function, nTS slices were made for whole-cell electrophysiological recordings. EAAT1 and 2 in the nTS was confirmed by RT-PCR, immunoblot and immunohistochemistry. EAAT2 mRNA was greater than EAAT1 in N, 1 and 3 d SH. One day SH did not alter EAAT 1 & 2 RT-PCR, immunoblots and immunohistochemistry. 3 d SH did not alter EAAT1 RT-PCR or immunoblots, but increased EAAT2 mRNA with a trend for increased protein. Functionally, blockade of EAAT2 with dihydrokainate (DHK, 300µM) produced a significant inward current and depolarization of membrane potential. These effects were reduced in slices from 3-days SH but not 1-day SH. These data suggest that SH alters the expression and function of EAAT2 which may have a nueroprotective effect. Grant Funding Source: Supported by: RO1 HL098602" @default.
- W1926553611 created "2016-06-24" @default.
- W1926553611 creator A5012579287 @default.
- W1926553611 creator A5056696021 @default.
- W1926553611 creator A5060937291 @default.
- W1926553611 creator A5071112632 @default.
- W1926553611 date "2014-04-01" @default.
- W1926553611 modified "2023-10-16" @default.
- W1926553611 title "Sustained hypoxia alters expression and function of excitatory amino acid transporters in the nucleus of the solitary tract (1127.2)" @default.
- W1926553611 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1127.2" @default.
- W1926553611 hasPublicationYear "2014" @default.
- W1926553611 type Work @default.
- W1926553611 sameAs 1926553611 @default.
- W1926553611 citedByCount "0" @default.
- W1926553611 crossrefType "journal-article" @default.
- W1926553611 hasAuthorship W1926553611A5012579287 @default.
- W1926553611 hasAuthorship W1926553611A5056696021 @default.
- W1926553611 hasAuthorship W1926553611A5060937291 @default.
- W1926553611 hasAuthorship W1926553611A5071112632 @default.
- W1926553611 hasConcept C104317684 @default.
- W1926553611 hasConcept C112592302 @default.
- W1926553611 hasConcept C113657865 @default.
- W1926553611 hasConcept C126322002 @default.
- W1926553611 hasConcept C134018914 @default.
- W1926553611 hasConcept C149011108 @default.
- W1926553611 hasConcept C169760540 @default.
- W1926553611 hasConcept C170493617 @default.
- W1926553611 hasConcept C17077164 @default.
- W1926553611 hasConcept C178790620 @default.
- W1926553611 hasConcept C185263204 @default.
- W1926553611 hasConcept C185592680 @default.
- W1926553611 hasConcept C203014093 @default.
- W1926553611 hasConcept C204232928 @default.
- W1926553611 hasConcept C2776219046 @default.
- W1926553611 hasConcept C4141045 @default.
- W1926553611 hasConcept C529278444 @default.
- W1926553611 hasConcept C540031477 @default.
- W1926553611 hasConcept C55493867 @default.
- W1926553611 hasConcept C61174792 @default.
- W1926553611 hasConcept C71924100 @default.
- W1926553611 hasConcept C7836513 @default.
- W1926553611 hasConcept C86803240 @default.
- W1926553611 hasConceptScore W1926553611C104317684 @default.
- W1926553611 hasConceptScore W1926553611C112592302 @default.
- W1926553611 hasConceptScore W1926553611C113657865 @default.
- W1926553611 hasConceptScore W1926553611C126322002 @default.
- W1926553611 hasConceptScore W1926553611C134018914 @default.
- W1926553611 hasConceptScore W1926553611C149011108 @default.
- W1926553611 hasConceptScore W1926553611C169760540 @default.
- W1926553611 hasConceptScore W1926553611C170493617 @default.
- W1926553611 hasConceptScore W1926553611C17077164 @default.
- W1926553611 hasConceptScore W1926553611C178790620 @default.
- W1926553611 hasConceptScore W1926553611C185263204 @default.
- W1926553611 hasConceptScore W1926553611C185592680 @default.
- W1926553611 hasConceptScore W1926553611C203014093 @default.
- W1926553611 hasConceptScore W1926553611C204232928 @default.
- W1926553611 hasConceptScore W1926553611C2776219046 @default.
- W1926553611 hasConceptScore W1926553611C4141045 @default.
- W1926553611 hasConceptScore W1926553611C529278444 @default.
- W1926553611 hasConceptScore W1926553611C540031477 @default.
- W1926553611 hasConceptScore W1926553611C55493867 @default.
- W1926553611 hasConceptScore W1926553611C61174792 @default.
- W1926553611 hasConceptScore W1926553611C71924100 @default.
- W1926553611 hasConceptScore W1926553611C7836513 @default.
- W1926553611 hasConceptScore W1926553611C86803240 @default.
- W1926553611 hasIssue "S1" @default.
- W1926553611 hasLocation W19265536111 @default.
- W1926553611 hasOpenAccess W1926553611 @default.
- W1926553611 hasPrimaryLocation W19265536111 @default.
- W1926553611 hasRelatedWork W1544803716 @default.
- W1926553611 hasRelatedWork W1646563530 @default.
- W1926553611 hasRelatedWork W1965829837 @default.
- W1926553611 hasRelatedWork W2005242158 @default.
- W1926553611 hasRelatedWork W2022264643 @default.
- W1926553611 hasRelatedWork W2032212939 @default.
- W1926553611 hasRelatedWork W2066419715 @default.
- W1926553611 hasRelatedWork W2146048290 @default.
- W1926553611 hasRelatedWork W2292680075 @default.
- W1926553611 hasRelatedWork W2522131675 @default.
- W1926553611 hasVolume "28" @default.
- W1926553611 isParatext "false" @default.
- W1926553611 isRetracted "false" @default.
- W1926553611 magId "1926553611" @default.
- W1926553611 workType "article" @default.