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- W1926560051 endingPage "4519" @default.
- W1926560051 startingPage "4513" @default.
- W1926560051 abstract "Abstract Enhanced immune responses during secondary exposure to Ag result from the development of memory cells. In the present report we show that stimulation through one receptor on dual receptor CD4 cells can promote the generation of T cells capable of giving a memory response through the second receptor, even though the cells had not been previously exposed to the Ag recognized by the second receptor. Cloned cells generated from dual receptor memory T cells proliferated and secreted the same lymphokines after stimulation with either Ag. Independent recognition of both Ags by distinct TCRs was shown by production of variants that had lost either Ag specificity along with the corresponding TCR. Recognition of both Ags is MHC restricted, since the cells recognize Ag presented by self, but not non-self, MHC class II molecules. These results raise the possibility that one potential mechanism of maintaining specific memory to a given Ag is through stimulation by an unrelated Ag via the second TCR." @default.
- W1926560051 created "2016-06-24" @default.
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- W1926560051 date "1998-11-01" @default.
- W1926560051 modified "2023-10-14" @default.
- W1926560051 title "Self-Restricted Dual Receptor Memory T Cells" @default.
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- W1926560051 doi "https://doi.org/10.4049/jimmunol.161.9.4513" @default.
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- W1926560051 hasPublicationYear "1998" @default.
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